ArticlePloS one2017
OPTiM: Optical projection tomography integrated microscope using open-source hardware and software.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- iCAT as an open-source platform for axial rotation and high-resolution imaging of organoids and living organisms.Communications biology · 2025Article
- Optical projection tomography implemented for accessibility and low cost (Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2024Article
- An Experimental Platform for Tomographic Reconstruction of Tissue Images in Brightfield Microscopy.Sensors (Basel, Switzerland) · 2023Article
- Integration of cellular-resolution optical coherence tomography and Raman spectroscopy for discrimination of skin cancer cells with machine learning.Journal of biomedical optics · 2023Article
- Automated low-cost device to produce sub-micrometric polymer fibers based on blow spun method.HardwareX · 2021Article
- High resolution optical projection tomography platform for multispectral imaging of the mouse gut.Biomedical optics express · 2021Article
- zOPT: an open source optical projection tomography system and methods for rapid 3D zebrafish imaging.Biomedical optics express · 2020Article
- OptiJ: Open-source optical projection tomography of large organ samples.Scientific reports · 2019Article
- Gaussian Light Model in Brightfield Optical Projection Tomography.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the implementation of an OPT plate to perform optical projection tomography (OPT) on a commercial wide-field inverted microscope, using our open-source hardware and software. The OPT plate includes a tilt adjustment for alignment and a stepper motor for sample rotation as required by standard projection tomography. Depending on magnification requirements, three methods of performing OPT are detailed using this adaptor plate: a conventional direct OPT method requiring only the addition of a limiting aperture behind the objective lens; an external optical-relay method allowing conventional OPT to be performed at magnifications >4x; a remote focal scanning and region-of-interest method for improved spatial resolution OPT (up to ~1.6 μm). All three methods use the microscope's existing incoherent light source (i.e. arc-lamp) and all of its inherent functionality is maintained for day-to-day use. OPT acquisitions are performed on in vivo zebrafish embryos to demonstrate the implementations' viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.