ArticlePloS one2017
Anti-inflammatory properties of extracts from Chimonanthus nitens Oliv. leaf.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
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- Hypolipidemic effect of ethanol extract from Chimonanthus nitens Oliv. leaves in hyperlipidemia rats via activation of the leptin/JAK2/STAT3 pathway.Molecular medicine (Cambridge, Mass.) · 2022Article
- Anti-Inflammatory Activity of Mulberry Leaf Flavonoids In Vitro and In Vivo.International journal of molecular sciences · 2022Article
- RETRACTED: Assessment of 2-Pentadecyl-2-oxazoline Role on Lipopolysaccharide-Induced Inflammation on Early Stage Development of Zebrafish (Danio rerio)Life (Basel, Switzerland) · 2022Article
- Antibacterial activity and mechanism of flavonoids fromFrontiers in microbiology · 2022Article
- The Nutritional Properties, Chemical Compositions, and Functional Characteristics of the Aerial Parts ofFrontiers in nutrition · 2022Article
- Metabolite Profiling ofPlants (Basel, Switzerland) · 2021Article
- Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases.Plants (Basel, Switzerland) · 2021Review
- Comparative Chloroplast Genome Analyses of the Winter-Blooming Eastern Asian Endemic GenusFrontiers in genetics · 2021Article
- A Sulfated Polysaccharide fromMarine drugs · 2020Article
- Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs.Frontiers in cell and developmental biology · 2020Review
- Physical Map of FISH 5S rDNA and (AGGenes · 2019Article
- Macrophage Cytological Profiling and Anti-Inflammatory Drug Discovery.Assay and drug development technologies · 2019Article
- Shepherd's Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-Oxidative medicine and cellular longevity · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chimonanthus nitens Oliv. (CN) is a species in the family Calycanthaceae. Its leaf is widely used to make traditional herbal tea in southern China and has a wide range of therapeutic effects. The profile of the ethanol extracts from CN leaves was identified by UPLC-QTOF-MS/MS. Forty seven compounds were determined including organic acids, phenolic acids and derivatives, flavonoids, coumarins, fatty acids and other compounds. The effect of the CN extracts on the inflammatory damage in zebrafish and in RAW 264.7 cells was investigated. The extracts demonstrated a strong ability to inhibit the recruitment of neutrophils in LPS-stimulated zebrafish, but macrophage migration was not significantly affected. Pro-inflammatory cytokines (i.e., TNF-α, IL-6 and IL-1β) were also determined by q-PCR. The extracts strongly reduced mRNA expression of TNF-α, IL-6 but not IL-1β in zebrafish model, while significantly inhibited the production of the factors in the RAW 264.7 cells. Therefore, our results suggest that the ethanol extracts of CN leaves may serve as a source of nutraceutical compounds with anti-inflammatory properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.