SynthesisPloS one2017
Cumulative effects of prenatal-exposure to exogenous chemicals and psychosocial stress on fetal growth: Systematic-review of the human and animal evidence.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Vaping and Smoking in Pregnancy-A Meta-Analysis of Neurobehavioural Development in Prenatally Exposed Offspring.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools.Systematic reviews · 2020Pooled it
- Examining the predictive accuracy of metabolomics for small-for-gestational-age babies: a systematic review.BMJ open · 2019Pooled it
- Socio-Economic Status and Health: Evaluation of Human Biomonitored Chemical Exposure to Per- and Polyfluorinated Substances across Status.International journal of environmental research and public health · 2018Pooled it
- The combined impact of chemical and non-chemical stressors on adverse health outcomes: an overview of reviews from the epidemiological literature and experimental animal studies.Journal of exposure science & environmental epidemiology · 2026Review
- Exposome and mental health across the lifespan: research and clinical perspectives.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Does consumption of a high-fructose diet during pregnancy and lactation exacerbate the effects of maternal exposure to cadmium on development and metabolic function of mouse offspring?Journal of toxicology and environmental health. Part A · 2026Article
- The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025Article
- FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- FIGO committee opinion: Environmental drivers of gynecologic and reproductive health.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Influences of Chemical and Nonchemical Stressors on Health and Quality of Life in Fenceline Communities: A Community-Based Participatory Research Survey in Southeastern Pennsylvania.Environmental justice (Print) · 2025Article
- The potential effect modifying role of nutrition, physical activity, and body mass index on the association between air pollution and adverse birth and early-life health outcomes: a scoping review.Environmental research communications · 2025Article
- Development of the Navigation Guide Evidence-to-Decision Framework for Environmental Health: Version 1.0.Environmental science & technology · 2025Article
- Critical Windows of Maternal Exposure to Biothermal Stress and Birth Weight for Gestational Age in Western Australia.Environmental health perspectives · 2023Article
- Disparities in Toxic Chemical Exposures and Associated Neurodevelopmental Outcomes: A Scoping Review and Systematic Evidence Map of the Epidemiological Literature.Environmental health perspectives · 2023Article
- Prediction Models for Intrauterine Growth Restriction Using Artificial Intelligence and Machine Learning: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement.Environmental health : a global access science source · 2023Article
- Characterizing changes in behaviors associated with chemical exposures during the COVID-19 pandemic.PloS one · 2023Article
- Adapting to Climate Change: Leveraging Systems-Focused Multidisciplinary Research to Promote Resilience.International journal of environmental research and public health · 2022Review
- The Joint Effect of Perceived Psychosocial Stress and Phthalate Exposure on Hormonal Concentrations during the Early Stage of Pregnancy: A Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAdverse effects of prenatal stress or environmental chemical exposures on fetal growth are well described, yet their combined effect remains unclear.
objectivesTo conduct a systematic review on the combined impact and interaction of prenatal exposure to stress and chemicals on developmental outcomes.
methodsWe used the first three steps of the Navigation Guide systematic review. We wrote a protocol, performed a robust literature search to identify relevant animal and human studies and extracted data on developmental outcomes. For the most common outcome (fetal growth), we evaluated risk of bias, calculated effect sizes for main effects of individual and combined exposures, and performed a random effects meta-analysis of those studies reporting on odds of low birthweight (LBW) by smoking and socioeconomic status (SES).
resultsWe identified 17 human- and 22 animal-studies of combined chemical and stress exposures and fetal growth. Human studies tended to have a lower risk of bias across nine domains. Generally, we found stronger effects for chemicals than stress, and these exposures were associated with reduced fetal growth in the low-stress group and the association was often greater in high stress groups, with limited evidence of effect modification. We found smoking associated with significantly increased odds of LBW, with a greater effect for high stress (low SES; OR 4.75 (2.46-9.16)) compared to low stress (high SES; OR 1.95 (95% CI 1.53-2.48)). Animal studies generally had a high risk of bias with no significant combined effect or effect modification.
conclusionsWe found that despite concern for the combined effects of environmental chemicals and stress, this is still an under-studied topic, though limited available human studies indicate chemical exposures exert stronger effects than stress, and this effect is generally larger in the presence of stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.