ArticlePloS one2017
Screening for the protective effect target of deproteinized extract of calf blood and its mechanisms in mice with CCl4-induced acute liver injury.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanism of interaction betweenFood chemistry: X · 2026Article
- Peripheral serum iTRAQ-based proteomic characteristics of carbon tetrachloride-induced acute liver injury inToxicology reports · 2024Article
- Tim-4 alleviates acute hepatic injury by modulating homeostasis and function of NKT cells.Clinical and experimental immunology · 2024Article
- Synergistic Effects ofInternational journal of molecular sciences · 2023Article
- Liver Protection of a Low-Polarity Fraction fromMolecules (Basel, Switzerland) · 2023Article
- Protective effect of Sophora pachycarpa seed extract on carbon tetrachloride-induced toxicity in rats.BMC complementary medicine and therapies · 2022Article
- Ameliorative effect ofFrontiers in pharmacology · 2022Article
- The Potential Hepatoprotective Effect of Paeoniae Radix Alba in Thioacetamide-Induced Acute Liver Injury in Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma.Nature communications · 2021Article
- Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CClMolecules (Basel, Switzerland) · 2020Article
- Carbon Dots fromInternational journal of nanomedicine · 2020Article
- Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice.International journal of medical sciences · 2020Article
- Identification of hepatitis B virus and liver cancer bridge molecules based on functional module network.World journal of gastroenterology · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver injury is a common pathological basis of various liver diseases, and long-term liver injury is often an important initiation factor leading to liver fibrosis and even liver cirrhosis and hepatocellular carcinoma (HCC). It has been reported that deproteinized extract of calf blood (DECB) can inhibit the replication of hepatitis B virus and confers a protective effect on the liver after traumatic liver injury. However, few studies on the regulatory factors and mechanisms of DECB have been reported. In this current study, an acute mouse liver injury model was established with carbon tetrachloride (CCl4). The differentially expressed genes and related cell signal transduction pathways were screened using mRNA expression microarray. STEM software V1.3.6 was used for clustering gene functions, and the DAVID and KEGG databases were applied for the analysis. A total of 1355 differentially expressed genes were selected, among which nine were validated by RT-qPCR. The results showed that the Fas, IL1b, Pik3r1, Pik3r5, Traf2, Traf2, Csf2rb2, Map3k14, Pik3cd and Ppp3cc genes were involved in the regulation of DECB in an acute mouse liver injury model. Targets of the protective effects of DECB and its related mechanisms were found in mice with acute liver injury induced by carbon tetrachloride, which may provide an important theoretical basis for further DECB research.
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