ArticlePloS one2017
Simulating the origins of life: The dual role of RNA replicases as an obstacle to evolution.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- RNA World with Inhibitors.Entropy (Basel, Switzerland) · 2024Article
- RNA World Modeling: A Comparison of Two Complementary Approaches.Entropy (Basel, Switzerland) · 2022Article
- Learning vector quantization as an interpretable classifier for the detection of SARS-CoV-2 types based on their RNA sequences.Neural computing & applications · 2022Article
- Article
- Prebiotic Soup Components Trapped in Montmorillonite Nanoclay Form New Molecules: Car-Parrinello Ab Initio Simulations.Life (Basel, Switzerland) · 2019Article
- Submit a Topic Page to PLOS Computational Biology and Wikipedia.PLoS computational biology · 2018Article
- Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems.Life (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite years of study, it is still not clear how life emerged from inanimate matter and evolved into the complex forms that we observe today. One of the most recognized hypotheses for the origins of life, the RNA World hypothesis, assumes that life was sparked by prebiotic replicating RNA chains. In this paper, we address the problems caused by the interplay between hypothetical prebiotic RNA replicases and RNA parasitic species. We consider the coexistence of parasite RNAs and RNA replicases as well as the impact of parasites on the further evolution of replicases. For these purposes, we used multi-agent modeling techniques that allow for realistic assumptions regarding the movement and spatial interactions of modeled species. The general model used in this study is based on work by Takeuchi and Hogeweg. Our results confirm that the coexistence of parasite RNAs and replicases is possible in a spatially extended system, even if we take into consideration more realistic assumptions than Takeuchi and Hogeweg. However, we also showed that the presence of trade-off that takes into the account an RNA folding process could still pose a serious obstacle to the evolution of replication. We conclude that this might be a cause for one of the greatest transitions in life that took place early in evolution-the separation of the function between DNA templates and protein enzymes, with a central role for RNA species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.