ArticlePloS one2017
Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Study on the predictive model of delirium risk after surgery for elderly hip fractures based on meta-analysis.European geriatric medicine · 2025Pooled it
- The 2023 WSES guidelines on the management of trauma in elderly and frail patients.World journal of emergency surgery : WJES · 2024Guideline
- Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review.JAMA network open · 2023Pooled it
- Can individualized blood pressure control prevent delirium after surgery in high-risk patients with sleep disorders?BMC anesthesiology · 2025Trial
- Effect of Preoperative Oral Saline Administration on Postoperative Delirium in Older Persons: A Randomized Controlled Trial.Clinical interventions in aging · 2022Trial
- Trial
- Evolving Trends and Collaborative Networks in Postoperative Delirium Research: A Two-Decade Bibliometric Analysis.Brain and behavior · 2026Article
- Identification of Risk Factors and Development of a Prediction Model for Recovery Room Delirium Following Transurethral Resection of the Prostate.Clinical interventions in aging · 2026Article
- Metabolic syndrome and perioperative neurocognitive disorders: epidemiology, mechanisms, and interventions.Frontiers in neuroscience · 2026Review
- How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution.Frontiers in psychiatry · 2024Article
- Association between intraoperative mean arterial pressure variability and postoperative delirium after hip fracture surgery: a retrospective cohort study.BMC geriatrics · 2023Article
- Comparison of restrictive fluid therapy with goal-directed fluid therapy for postoperative delirium in patients undergoing spine surgery: a randomized controlled trial.Perioperative medicine (London, England) · 2021Article
- Impact of Physical Activity on Disability Risk in Elderly Patients Hospitalized for Mild Acute Diverticulitis and Diverticular Bleeding Undergone Conservative Management.Medicina (Kaunas, Lithuania) · 2021Article
- Commentary on "Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Postoperative Delirium".Geriatric orthopaedic surgery & rehabilitation · 2021Article
- Investigating Association between Intraoperative Hypotension and Postoperative Neurocognitive Disorders in Non-Cardiac Surgery: A Comprehensive Review.Journal of clinical medicine · 2020Review
- Electroencephalogram Burst-suppression during Cardiopulmonary Bypass in Elderly Patients Mediates Postoperative Delirium.Anesthesiology · 2020Article
- American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention.Anesthesia and analgesia · 2020Article
- Development of a Risk Score to Predict Postoperative Delirium in Patients With Hip Fracture.Anesthesia and analgesia · 2020Article
- Physical Activity and Risk of Postoperative Delirium.Journal of the American Geriatrics Society · 2019Article
- Improving Perioperative Outcomes Through Minimally Invasive and Non-invasive Hemodynamic Monitoring Techniques.Frontiers in medicine · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelirium is common in hip fracture patients and many risk factors have been identified. Controversy exists regarding the possible impact of intraoperative control of blood pressure upon acute (delirium) and long term (dementia) cognitive decline. We explored possible associations between perioperative hemodynamic changes, use of vasopressor drugs, risk of delirium and risk of new-onset dementia.
methodsProspective follow-up study of 696 hip fracture patients, assessed for delirium pre- and postoperatively, using the Confusion Assessment Method. Pre-fracture cognitive function was assessed using the Informant Questionnaire of Cognitive Decline in the Elderly and by consensus diagnosis. The presence of new-onset dementia was determined at follow-up evaluation at six or twelve months after surgery. Blood pressure was recorded at admission, perioperatively and postoperatively.
resultsPreoperative delirium was present in 149 of 536 (28%) assessable patients, and 124 of 387 (32%) developed delirium postoperatively (incident delirium). The following risk factors for incident delirium in patients without pre-fracture cognitive impairment were identified: low body mass index, low level of functioning, severity of physical illness, and receipt of ≥ 2 blood transfusions. New-onset dementia was diagnosed at follow-up in 26 of 213 (12%) patients, associated with severity of physical illness, delirium, receipt of vasopressor drugs perioperatively and high mean arterial pressure postoperatively.
conclusionRisk factors for incident delirium seem to differ according to pre-fracture cognitive status. The use of vasopressors during surgery and/or postoperative hypertension is associated with new-onset dementia after hip fracture.
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