Evidence map›Paper›PMID 28700536›Full record

ArticlePain2017

Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.

Vijay K Samineni, Jangyeol Yoon, Kaitlyn E Crawford, Yu Ra Jeong, Kajanna C McKenzie, Gunchul Shin, Zhaoqian Xie, Saranya S Sundaram, Yuhang Li, Min Young Yang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Soft, Flexible, and Stretchable Platforms for Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Towards translational optogenetics.Nature biomedical engineering · 2023
    Review
  17. Review
  18. Review
  19. Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 3 countries.

Vijay K SamineniWashington University Pain Center and.
Jangyeol YoonDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Kaitlyn E CrawfordDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Yu Ra JeongDepartment of Chemical and Biological Engineering, KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
Kajanna C McKenzieWashington University Pain Center and.
Gunchul ShinDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Zhaoqian XieDepartments of Civil and Environmental Engineering, Mechanical Engineering, Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Saranya S SundaramWashington University Pain Center and.
Yuhang LiSchool of Aeronautic Science and Engineering, Institute of Solid Mechanics, Beihang University (BUAA), Beijing, China.
Min Young YangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Jeonghyun KimDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Di WuDepartments of Civil and Environmental Engineering, Mechanical Engineering, Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Yeguang XueDepartments of Civil and Environmental Engineering, Mechanical Engineering, Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Xue FengAML, Department of Engineering Mechanics, Center for Mechanics and Materials, Tsien Excellent Education Program, School of Aerospace, Tsinghua University, Beijing, China.
Yonggang HuangDepartments of Civil and Environmental Engineering, Mechanical Engineering, Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Aaron D MickleWashington University Pain Center and.
Anthony BanksDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Jeong Sook HaDepartment of Chemical and Biological Engineering, KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
Judith P GoldenWashington University Pain Center and.
John A RogersDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Kim is now with the Department of Electronics Convergence Engineering, Kwangwoon University, Seoul, Republic of Korea.
Robert W GereauWashington University Pain Center and.
Washington University in St. Louis · USKwangwoon University · KRNorthwestern University · USUniversity of Illinois Urbana-Champaign · USKorea University · KRTsinghua University · CNBeihang University · CN

Funding

MECHANISMS OF PERIPHERAL MGLUR MODULATION OF NOCICEPTIONR01NS042595 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2002 to 2017
$5.2M
MECHANISMS OF CENTRAL SENSITIZATIONR01NS048602 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2004 to 2014
$4.2M
Multimodal biocompatible microLED devices for diverse neuroscience applicationsR01NS081707 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W, ROGERS, JOHN · 2012 to 2016
$3.9M
NINDS NIH HHS R01 NS042595NINDS NIH HHS R01 NS048602NINDS NIH HHS R01 NS081707
6 · The paper itself

Abstract

The advent of optogenetic tools has allowed unprecedented insights into the organization of neuronal networks. Although recently developed technologies have enabled implementation of optogenetics for studies of brain function in freely moving, untethered animals, wireless powering and device durability pose challenges in studies of spinal cord circuits where dynamic, multidimensional motions against hard and soft surrounding tissues can lead to device degradation. We demonstrate here a fully implantable optoelectronic device powered by near-field wireless communication technology, with a thin and flexible open architecture that provides excellent mechanical durability, robust sealing against biofluid penetration and fidelity in wireless activation, thereby allowing for long-term optical stimulation of the spinal cord without constraint on the natural behaviors of the animals. The system consists of a double-layer, rectangular-shaped magnetic coil antenna connected to a microscale inorganic light-emitting diode (μ-ILED) on a thin, flexible probe that can be implanted just above the dura of the mouse spinal cord for effective stimulation of light-sensitive proteins expressed in neurons in the dorsal horn. Wireless optogenetic activation of TRPV1-ChR2 afferents with spinal μ-ILEDs causes nocifensive behaviors and robust real-time place aversion with sustained operation in animals over periods of several weeks to months. The relatively low-cost electronics required for control of the systems, together with the biocompatibility and robust operation of these devices will allow broad application of optogenetics in future studies of spinal circuits, as well as various peripheral targets, in awake, freely moving and untethered animals, where existing approaches have limited utility.

Indexed as

OptogeneticsWireless TechnologyAnimalsCalcitonin Gene-Related PeptideCalcium-Binding ProteinsDisease Models, AnimalElectromagnetic PhenomenaExploratory BehaviorGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsLocomotionMaleMiceMice, TransgenicMicrofilament ProteinsSpinal CordAif1 protein, mouseCalcitonin Gene-Related PeptideCalcium-Binding Proteinsenhanced green fluorescent proteinGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsMicrofilament ProteinsTRPV1 protein, mouseTRPV Cation Channels

Identifiers

PMID28700536
PMCPMC5640477
OpenAlexW2735867997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.