ArticleMedicine2017
Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Bacteria-Associated Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024Review
- Analysis of 13-valent pneumococcal polysaccharide conjugate vaccine among children born in Hangzhou from 2017 to 2021.Frontiers in public health · 2023Article
- Sepsis as the Grand Mimic of Secondary Hemophagocytic Lymphohistiocytosis:Case reports in critical care · 2023Article
- The first case of Streptococcus intermedius brain abscess with hemophagocytic histiocytosis.BMC infectious diseases · 2022Article
- Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: a pediatric case report.BMC pediatrics · 2020Article
- Fatal case of hemophagocytic lymphohistiocytosis associated with group B streptococcus sepsis: A case report.Medicine · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleHemophagocytic lymphohistiocytosis (HLH) is a syndrome that is characterized by an inappropriate hyperinflammatory immune response - primary, as a consequence of a genetic defect of NK cells and cytotoxic T lymphocytes or - secondary, in the progression of infections, rheumatic or autoimmune diseases, malignancies or metabolic diseases. PATIENT CONCERNS: We present the case of a secondary HLH due to Streptococcus pneumoniae infection in a splenectomised patient for spherocytosis, a 37-year-old patient who was splenectomised in childhood for spherocytosis, without immuneprophylaxis induced by antipneumococcal vaccine. OUTCOMES: He developed a severe pneumococcal sepsis associated with secondary HLH, with unfavorable outcome and death. LESSONS: To our knowledge, just 2 similar cases had been published in the literature, none in which the secondary HLH was the consequence of an invasive pneumococcal infection in a splenectomized patient for spherocytosis, and the association of splenectomy with HLH is surprizin.
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Registered trials
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