Observational studyMedicine2017
Peripheral monocytosis as a predictive factor for adverse outcome in the emergency department: Survey based on a register study.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Gender Characteristics of the Novel Coronavirus Infection (COVID-19) in Middle-Aged Adults.Sovremennye tekhnologii v meditsine · 2021Trial
- Variability of the lymphocyte-to-monocyte ratio in patients with chronic kidney disease on hemodialysis.PloS one · 2025Article
- Clinical characteristics and prognostic marker for hospitalization in children with influenza infection in an emergency setting.BMC pediatrics · 2024Article
- Clinical Characteristics and Outcomes of Pediatric COVID-19 Pneumonia Treated with Favipiravir in a Tertiary Care Center.Viruses · 2024Article
- Analysis of hematological parameters in rheumatoid arthritis patients receiving biological therapy: contribution to prevention of avoidable hematological complications.EXCLI journal · 2022Article
- Differential Diagnosis and Workup of Monocytosis: A Systematic Approach to a Common Hematologic Finding.Current hematologic malignancy reports · 2021Review
- Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis.Current hematologic malignancy reports · 2021Review
- Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV.HIV medicine · 2021Article
- Article
- Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.Molecular medicine (Cambridge, Mass.) · 2020Article
- Peripheral monocyte count is an independent predictor of all-cause mortality in type 2 diabetes with macro-vascular complications.Medicine · 2020Observational
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocytosis is associated with chronic infections such as tuberculosis or endocarditis as well as rheumatic and myeloproliferative disorders. Monocytes are also involved in the pathogenesis of atherosclerosis, coronary artery disease, and stroke. The value of monocytosis as a prognostic marker in different diagnostic groups in the emergency setting, however, has not been investigated so far.The aim of the article is to study monocytosis as an outcome factor in the emergency setting.In a Swiss register study, we analyzed monocyte counts in 4238 patients aged >18 years who were admitted to the emergency department of a regional tertiary care hospital. Monocytosis was defined as 0.8×10 cells/L. Diagnoses were grouped into infection, cardiovascular, neurological, metabolic, gastrointestinal, pulmonary, or other. Thirty-day mortality was defined as the primary endpointA total of 1217 patients with monocytosis were identified. Patients with monocytosis at admission suffered more frequently from respiratory symptoms (17.7% vs 8.9%, P <.001) and infection as the final diagnosis (20.8% vs 10.3%, P <.001) while neurological diagnoses were significantly lower in the monocytosis group (15.3% vs 30.9%, P <.001). Patients with monocytosis suffered from more comorbidities such as congestive heart failure, chronic obstructive pulmonary disease, tumor, diabetes, or renal failure but not dementia. When adjusted for age, gender, comorbidities, and main diagnosis, the 30-day mortality (P = .002) and length of stay (P = .001) were significantly higher in patients with monocytosis. The 30-day mortality in patients with monocytosis was most notably influenced by a cardiological diagnosis (odds ratio 3.91).An increased monocyte count predicts adverse outcome in patients admitted to the emergency department. Mechanistic studies will be necessary to specify the potentially detrimental role of monocytosis in critical illness.
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