Evidence map›Paper›PMID 28700459›Full record

ArticlePsychosomatic medicine2017

The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls: An Exploratory Study.

Sian M J Hemmings, Stefanie Malan-Müller, Leigh L van den Heuvel, Brittany A Demmitt, Maggie A Stanislawski, David G Smith, Adam D Bohr, Christopher E Stamper, Embriette R Hyde, James T Morton and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 12 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 12 syntheses or guidelines pooled it, 202 citations in OpenAlex.

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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 2 countries.

Sian M J HemmingsFrom the Department of Psychiatry (Hemmings, Malan-Müller, van den Heuvel, Seedat), Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa; Departments of Molecular, Cellular and Developmental Biology (Demmitt, Krauter), Chemistry and Biochemistry (Smith), and Integrative Physiology (Bohr, Stamper, Siebler, McQueen, Lowry), Institute for Behavioral Genetics (Demmitt, Bohr, McQueen, Krauter), and Center for Neuroscience (Lowry), University of Colorado Boulder, Boulder; Departments of Epidemiology (Stanislawski), Psychiatry and Neurology (Brenner), and Physical Medicine and Rehabilitation (Brenner, Lowry), and Center for Neuroscience (Lowry), University of Colorado Anschutz Medical Campus, Aurora; US Department of Veterans Affairs (Stanislawski), Denver, CO; Departments of Pediatrics (Hyde, Marotz, Knight) and Computer Science & Engineering (Morton, Knight), and Center for Microbiome Innovation (Knight), University of California San Diego, La Jolla, CA; NXT-Dx (Braspenning); Department of Mathematical Modelling (Van Criekinge), Statistics and Bio-informatics, Ghent University, Gent, Belgium; Department of Civil and Environmental Engineering (Hoisington), United States Air Force Academy, Colorado Springs; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE) (Hoisington, Brenner, Postolache, Lowry); VA Rocky Mountain Mental Illness Research, Education, and Clinical Center (MIRECC) (Brenner, Postolache, Lowry), Denver, CO; and Department of Psychiatry (Postolache), School of Medicine, University of Maryland, Baltimore, MD.
Stefanie Malan-Müller
Leigh L van den Heuvel
Brittany A Demmitt
Maggie A Stanislawski
David G Smith
Adam D Bohr
Christopher E Stamper
Embriette R Hyde
James T Morton
Clarisse A Marotz
Philip H Siebler
Maarten Braspenning
Wim Van Criekinge
Andrew J Hoisington
Lisa A Brenner
Teodor T Postolache
Matthew B McQueen
Kenneth S Krauter
Rob Knight
Soraya Seedat
Christopher A Lowry
Lowry Memorial College & Group of Institutions · INStellenbosch University · ZA

Funding

University of Colorado Population CenterP2CHD066613 · NICHD · UNIVERSITY OF COLORADO · PI JANE A MENKEN · 2015 to 2026
$3.7M
Neural Sensitivity to Stress During Drug WithdrawalR01DA019921 · NIDA · UNIVERSITY OF SOUTH DAKOTA · PI FORSTER, GINA L · 2005 to 2015
$2.4M
Mechanisms Underlying Stress-Induced Activation of Serotonergic SystemsR01MH086539 · NIMH · UNIVERSITY OF COLORADO · PI LOWRY, CHRISTOPHER A · 2009 to 2012
$1.2M
Biological Signature and Safety of an Immunomodulatory Probiotic Intervention for Veterans with Co-Occuring Mild TBI and PTSDI21RX002232 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI BRENNER, LISA A · 2016 to 2018
–
NICHD NIH HHS P2C HD066613NIDA NIH HHS R01 DA019921NIMH NIH HHS R01 MH086539RRD VA I21 RX002232
6 · The paper itself

Abstract

objectiveInadequate immunoregulation and elevated inflammation may be risk factors for posttraumatic stress disorder (PTSD), and microbial inputs are important determinants of immunoregulation; however, the association between the gut microbiota and PTSD is unknown. This study investigated the gut microbiome in a South African sample of PTSD-affected individuals and trauma-exposed (TE) controls to identify potential differences in microbial diversity or microbial community structure.

methodsThe Clinician-Administered PTSD Scale for DSM-5 was used to diagnose PTSD according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Microbial DNA was extracted from stool samples obtained from 18 individuals with PTSD and 12 TE control participants. Bacterial 16S ribosomal RNA gene V3/V4 amplicons were generated and sequenced. Microbial community structure, α-diversity, and β-diversity were analyzed; random forest analysis was used to identify associations between bacterial taxa and PTSD.

resultsThere were no differences between PTSD and TE control groups in α- or β-diversity measures (e.g., α-diversity: Shannon index, t = 0.386, p = .70; β-diversity, on the basis of analysis of similarities: Bray-Curtis test statistic = -0.033, p = .70); however, random forest analysis highlighted three phyla as important to distinguish PTSD status: Actinobacteria, Lentisphaerae, and Verrucomicrobia. Decreased total abundance of these taxa was associated with higher Clinician-Administered PTSD Scale scores (r = -0.387, p = .035).

conclusionsIn this exploratory study, measures of overall microbial diversity were similar among individuals with PTSD and TE controls; however, decreased total abundance of Actinobacteria, Lentisphaerae, and Verrucomicrobia was associated with PTSD status.

Indexed as

Gastrointestinal MicrobiomeAdultDNA, BacterialFecesFemaleHumansMaleMiddle AgedPilot ProjectsPsychological TraumaRNA, BacterialRNA, Ribosomal, 16SStress Disorders, Post-TraumaticDNA, BacterialRNA, BacterialRNA, Ribosomal, 16S

Identifiers

PMID28700459
PMCPMC5763914
OpenAlexW2734898627

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.