Evidence map›Paper›PMID 28699397›Full record

ArticleTissue engineering. Part A2017

Anthony Monteforte, Brian Lam, Michael B Sherman, Kayla Henderson, Andrew D Sligar, Adrianne Spencer, Brian Tang, Andrew K Dunn, Aaron B Baker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Theranostic signature of tumor-derived exosomes in cancer.Medical oncology (Northwood, London, England) · 2023
    Review
  8. Review
  9. Exosomes for angiogenesis induction in ischemic disorders.Journal of cellular and molecular medicine · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Therapeutic Biomaterial Approaches to Alleviate Chronic Limb Threatening Ischemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  16. Review
  17. Review
  18. Role of Exosomes in the Progression, Diagnosis, and Treatment of Gliomas.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anthony Monteforte1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Brian Lam1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Michael B Sherman2 Department of Biochemistry and Molecular Biology, University of Texas Medical Branch , Galveston, Texas.
Kayla Henderson1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Andrew D Sligar1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Adrianne Spencer1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Brian Tang1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Andrew K Dunn1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
Aaron B Baker1 Department of Biomedical Engineering, University of Texas at Austin , Texas.
The University of Texas at Austin · USThe University of Texas Medical Branch at Galveston · US

Funding

Optical Imaging of Baseline Blood Flow and Oxygenation During StrokeR01EB011556 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2010 to 2018
$3.1M
Engineering Effective Revascularization Strategies for Ischemia in Disease StatesDP2OD008716 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2011 to 2011
$2.3M
NIBIB NIH HHS R01 EB011556NIH HHS DP2 OD008716
6 · The paper itself

Abstract

Peripheral ischemia as a result of occlusive vascular disease is a widespread problem in patients older than the age of 65. Angiogenic therapies that can induce microvascular growth have great potential for providing a long-lasting solution for patients with ischemia and would provide an appealing alternative to surgical and percutaneous interventions. However, many angiogenic therapies have seen poor efficacy in clinical trials, suggesting that patients with long-term peripheral ischemia have considerable therapeutic resistance to angiogenic stimuli. Glioblastoma is one of the most angiogenic tumor types, inducing robust vessel growth in the area surrounding the tumor. One major angiogenic mechanism used by the tumor cells to induce blood vessel growth is the production of exosomes and other extracellular vesicles that can carry pro-angiogenic and immunomodulatory signals. Here, we explored whether the pro-angiogenic aspects of glioblastoma-derived exosomes could be harnessed to promote angiogenesis and healing in the context of peripheral ischemic disease. We demonstrate that the exosomes derived from glioblastoma markedly enhance endothelial cell proliferation and increase endothelial tubule formation in vitro. An analysis of the microRNA expression using next generation sequencing identified that exosomes contained a high concentration of miR-221. In addition, we found that glioblastoma exosomes contained significant amounts of the proteoglycans glypican-1 and syndecan-4, which can serve as co-receptors for angiogenic factors, including fibroblast growth factor-2 (FGF-2). In a hindlimb ischemia model in mice, we found that the exosomes promoted enhanced revascularization in comparison to control alginate gels and FGF-2 treatment alone. Taken together, our results support the fact that glioblastoma-derived exosomes have powerful effects in increasing revascularization in the context of peripheral ischemia.

Indexed as

Neovascularization, PhysiologicAnimalsBrain NeoplasmsCell Line, TumorCell ProliferationExosomesFibroblast Growth Factor 2GlioblastomaHindlimbHumansHuman Umbilical Vein Endothelial CellsIschemiaMice, Inbred C57BLRNA, NeoplasmFibroblast Growth Factor 2RNA, NeoplasmexosomesglioblastomaischemiamiR-221therapeutic angiogenesis

Identifiers

PMID28699397
PMCPMC5689131
OpenAlexW2736053448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.