Evidence map›Paper›PMID 28699352›Full record

ReviewAntioxidants & redox signaling2017

Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition.

Britta Kunkemoeller, Themis R Kyriakides

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants & redox signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05908513 (Randomized Study on N-acetylcysteine Treatment and Outcomes in Patients With Advanced Atherosclerotic Heart Diseases and Diabetes Mellitus), which is not on this map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05908513 phase1withdrawnnot on this mapstarted 2021, after this paper: background citation

Randomized Study on N-acetylcysteine Treatment and Outcomes in Patients With Advanced Atherosclerotic Heart Diseases and Diabetes Mellitus (RENEWAL)

TypeinterventionalSponsorUniversity of Missouri-ColumbiaRan2021 to 2021Enrolled0ConditionsAtherosclerosis of Artery, Peripheral Artery Disease, Diabetes Mellitus, InflammationArmsN-acetylcysteine, Placebo
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 221 citations in OpenAlex.

  1. Review
  2. A bilayer hydrogel with a lower layer ROS-responsive Au-CeOInternational journal of pharmaceutics: X · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Britta Kunkemoeller1 Department of Pathology, Yale University School of Medicine , New Haven, Connecticut.
Themis R Kyriakides1 Department of Pathology, Yale University School of Medicine , New Haven, Connecticut.
Yale University · US

Funding

MCP-1 and attenuation of the foreign body responseR01GM072194 · NIGMS · YALE UNIVERSITY · PI KYRIAKIDES, THEMIS R · 2005 to 2018
$4.7M
Training Program in Molecular MedicineT32GM100884 · NIGMS · YALE UNIVERSITY · PI LISTER, GEORGE, NITABACH, MICHAEL · 2013 to 2022
$1.8M
NIGMS NIH HHS R01 GM072194NIGMS NIH HHS T32 GM100884
6 · The paper itself

Abstract

significanceImpaired wound healing is a major complication of diabetes, and can lead to development of chronic foot ulcers in a significant number of patients. Despite the danger posed by poor healing, very few specific therapies exist, leaving patients at risk of hospitalization, amputation, and further decline in overall health. Recent Advances: Redox signaling is a key regulator of wound healing, especially through its influence on the extracellular matrix (ECM). Normal redox signaling is disrupted in diabetes leading to several pathological mechanisms that alter the balance between reactive oxygen species (ROS) generation and scavenging. Importantly, pathological oxidative stress can alter ECM structure and function. CRITICAL ISSUES: There is limited understanding of the specific role of altered redox signaling in the diabetic wound, although there is evidence that ROS are involved in the underlying pathology. FUTURE DIRECTIONS: Preclinical studies of antioxidant-based therapies for diabetic wound healing have yielded promising results. Redox-based therapeutics constitute a novel approach for the treatment of wounds in diabetes patients that deserve further investigation. Antioxid. Redox Signal. 27, 823-838.

Indexed as

Wound HealingAnimalsAntioxidantsDiabetes ComplicationsDisease Models, AnimalExtracellular MatrixHumansOxidation-ReductionOxidative StressReactive Oxygen SpeciesSignal TransductionAntioxidantsReactive Oxygen Speciescollagendiabetesextracellular matrixreactive oxygen specieswound healing

Identifiers

PMID28699352
PMCPMC5647483
OpenAlexW2734455709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.