ArticleEnvironmental science & technology2017
Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells.
Article in Environmental science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways.Archives of toxicology · 2026Article
- Identification of pharmaceuticals and environmental contaminants as obesogens inducing a locomotion-independent thrifty phenotype.Communications biology · 2026Article
- Mixtures ofToxics · 2025Article
- Article
- Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish.Environmental toxicology and chemistry · 2025Article
- Defining the role of 2,2',4,4'-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis.Adipocyte · 2024Article
- Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish.bioRxiv : the preprint server for biology · 2024Article
- Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model.Environmental science & technology · 2023Article
- Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures.The Science of the total environment · 2023Article
- Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat.Frontiers in toxicology · 2023Article
- Widespread formation of toxic nitrated bisphenols indoors by heterogeneous reactions with HONO.Science advances · 2022Article
- On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals.Environmental health perspectives · 2022Review
- Obesity II: Establishing causal links between chemical exposures and obesity.Biochemical pharmacology · 2022Review
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- Understanding exposures and latent disease risk within the National Institute of Environmental Health Sciences Superfund Research Program.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish.Toxics · 2022Article
- Adipogenic Activity of Chemicals Used in Plastic Consumer Products.Environmental science & technology · 2022Article
- Characterization of Per- and Polyfluorinated Alkyl Substances Present in Commercial Anti-fog Products and TheirEnvironmental science & technology · 2022Article
- Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study.Toxicology · 2021Article
- Characterization of adipogenic, PPARγ, and TRβ activities in house dust extracts and their associations with organic contaminants.The Science of the total environment · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obesity and metabolic disorders are of great societal concern and generate significant human health care costs. Recently, attention has focused on the potential for environmental contaminants to act as metabolic disruptors. This study sought to evaluate the adipogenic activity of indoor house dust extracts and a suite of semivolatile organic chemicals (SVOCs) that are often ubiquitously detected in indoor environments. 3T3-L1 cells were exposed to extracts of indoor dust or individual SVOCs and assessed for triglyceride accumulation and preadipocyte proliferation. Ten of 11 house dust extracts exhibited significant triglyceride accumulation and/or proliferation at environmentally relevant levels (<20 μg of dust/well), and significant adipogenic activity was also exhibited by 28 of the SVOCs. Notably, pyraclostrobin, dibutyl phthalate, tert-butyl-phenyl diphenyl phosphate, and the isopropylated triaryl phosphates (ITPs) exhibited near maximal or supra-maximal triglyceride accumulation relative to the rosiglitazone-induced maximum. The adipogenic activity in house dust occurred at concentrations below EPA estimated child exposure levels, and raises concerns for human health impacts, particularly in children. Our results delineate a novel potential health threat and identify putative causative SVOCs that are likely contributing to this activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.