ArticleThe European journal of neuroscience2017
Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking.
Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 65 citations in OpenAlex.
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Differential contributions of striatal dopaminergic pathways to visuomotor conditional learning.Psychopharmacology · 2026Article
- Dopamine and Acetylcholine in the Striatum: Circuit Interactions and Behavioral Control in Substance Use Disorders.Brain sciences · 2026Review
- Phasic dopamine encodes persistent attraction to reward cues.bioRxiv : the preprint server for biology · 2025Article
- Sequence termination cues drive habits via dopamine-mediated credit assignment.bioRxiv : the preprint server for biology · 2025Article
- Modulation of Dopamine Neurons Alters Behavior and Event Encoding in the Nucleus Accumbens during Pavlovian Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Nucleus Accumbens Dopamine Encodes the Trace Period during Appetitive Pavlovian Conditioning.eNeuro · 2025Article
- Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system.Current biology : CB · 2025Article
- Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice.Current biology : CB · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
- Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats.Scientific reports · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.bioRxiv : the preprint server for biology · 2024Article
- Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice.bioRxiv : the preprint server for biology · 2023Article
- Contexts facilitate dynamic value encoding in the mesolimbic dopamine system.bioRxiv : the preprint server for biology · 2023Article
- Decreased Ventral Tegmental Area CB1R Signaling Reduces Sign Tracking and Shifts Cue-Outcome Dynamics in Rat Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Nicotinic and muscarinic acetylcholine receptor antagonism dose-dependently decreases sign- but not goal-tracking behavior in male rats.Psychopharmacology · 2023Article
- Article
- Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues.Nature communications · 2022Article
- Critical periods when dopamine controls behavioral responding during Pavlovian learning.Psychopharmacology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The attribution of incentive salience to reward-paired cues is dependent on dopamine release in the nucleus accumbens core (NAcC). These dopamine signals conform to traditional reward-prediction error signals and have been shown to diminish with time. Here we examined whether the diminishing dopamine signal in the NAcC has functional implications for the expression of sign-tracking, a Pavlovian conditioned response indicative of the attribution of incentive salience to reward-paired cues. Food-restricted male Sprague Dawley rats were trained in a Pavlovian paradigm in which an insertable lever predicted delivery of food reward in a nearby food cup. After 7 or 14 training sessions, rats received infusions of saline, the dopamine antagonist flupenthixol, or the GABA agonists baclofen and muscimol into the NAcC or the dorsal lateral striatum (DLS). Dopamine antagonism within the NAcC attenuated sign-tracking, whereas reversible inactivation did not affect sign-tracking but increased non-specific food cup checking behaviors. Neither drug in the DLS affected sign-tracking behavior. Critically, extended training did not alter these effects. Although extended experience with an incentive stimulus may reduce cue-evoked dopamine in the NAcC, this does not remove the dependence on dopamine in this region to promote Pavlovian cue approach nor result in the recruitment of dorsal lateral striatal systems for this behavior. These data support the notion that dopamine within the mesoaccumbal system, but not the nigrostriatal system, contributes critically to incentive motivational processes independent of the length of training.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.