ArticleEpilepsia2017
Automated T2 relaxometry of the hippocampus for temporal lobe epilepsy.
Article in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigatory pathway and principles of patient selection for epilepsy surgery candidates: a systematic review.BMC neurology · 2020Pooled it
- Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy.Neurology · 2026Article
- FGF10 ameliorates epileptic seizures and related cognitive dysfunction via the FGFR2/CALB1 signaling pathway.Journal of translational medicine · 2025Article
- Enhancing Hippocampal Subfield Visualization Through Deep Learning Reconstructed MRI Scans.Diagnostics (Basel, Switzerland) · 2025Article
- MRI-T2 Relaxometry is Increased in Mild Traumatic Brain Injury: Indications of Acute Brain Abnormalities After Injury.Journal of neuroscience research · 2025Article
- The Little-Known Ribbon-Shaped Piriform Cortex: A Key Node in Temporal Lobe Epilepsy-Anatomical Insights and Its Potential for Surgical Treatment.Diagnostics (Basel, Switzerland) · 2024Review
- Granulation Patterns of Functional Corticotroph Tumors Correlate with Tumor Size, Proliferative Activity, T2 Intensity-to-White Matter Ratio, and Postsurgical Early Biochemical Remission.Endocrine pathology · 2024Article
- Widespread, depth-dependent cortical microstructure alterations in pediatric focal epilepsy.Epilepsia · 2024Article
- Individual-level analysis of MRI T2 relaxometry in mild traumatic brain injury: Possible indications of brain inflammation.NeuroImage. Clinical · 2024Article
- Clinical Evaluation of a Quantitative Imaging Biomarker Supporting Radiological Assessment of Hippocampal Sclerosis.Clinical neuroradiology · 2023Article
- Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.Brain : a journal of neurology · 2023Article
- Longitudinal hippocampal diffusion-weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy.Epilepsia open · 2023Article
- Combined quantitative T2 mapping and [European radiology · 2022Article
- Volumetric analysis of the piriform cortex in temporal lobe epilepsy.Epilepsy research · 2022Article
- The Learning Curve and Inter-Observer Variability in Contouring the Hippocampus under the Hippocampal Sparing Guidelines of Radiation Therapy Oncology Group 0933.Current oncology (Toronto, Ont.) · 2022Article
- Radiological identification of temporal lobe epilepsy using artificial intelligence: a feasibility study.Brain communications · 2022Article
- A Magnetic Resonance-Relaxometry-Based Technique to Identify Blood Products in Brain Parenchyma: An Experimental Study on a Rabbit Model.Frontiers in veterinary science · 2022Article
- MRI-Based Machine Learning Prediction Framework to Lateralize Hippocampal Sclerosis in Patients With Temporal Lobe Epilepsy.Neurology · 2021Article
- Histopathological Correlations of Qualitative and Quantitative Temporopolar MRI Analyses in Patients With Hippocampal Sclerosis.Frontiers in neurology · 2021Article
- Automatic multispectral MRI segmentation of human hippocampal subfields: an evaluation of multicentric test-retest reproducibility.Brain structure & function · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveHippocampal sclerosis (HS), the most common cause of refractory temporal lobe epilepsy, is associated with hippocampal volume loss and increased T2 signal. These can be identified on quantitative imaging with hippocampal volumetry and T2 relaxometry. Although hippocampal segmentation for volumetry has been automated, T2 relaxometry currently involves subjective and time-consuming manual delineation of regions of interest. In this work, we develop and validate an automated technique for hippocampal T2 relaxometry.
methodsFifty patients with unilateral or bilateral HS and 50 healthy controls underwent T
resultsHippocampal T2 values were reliably determined using the automated method. There was a significant ipsilateral increase in T2 values in HS (p < 0.001), and a smaller but significant contralateral increase. The combination of hippocampal volumes and T2 values separated the groups well. There was a strong correlation between automated and manual methods for hippocampal T2 measurement (0.917 left, 0.896 right, both p < 0.001). Interscan reproducibility was superior for automated compared to manual measurements. SIGNIFICANCE: Automated hippocampal segmentation can be reliably extended to the determination of hippocampal T2 values, and a combination of hippocampal volumes and T2 values can separate subjects with HS from healthy controls. There is good agreement with manual measurements, and the technique is more reproducible on repeat scans than manual measurement. This protocol can be readily introduced into a clinical workflow for the assessment of patients with focal epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.