Evidence map›Paper›PMID 28699178›Full record

ArticleJournal of magnetic resonance imaging : JMRI2018

Task-based changes in proton MR spectroscopy signal during configural working memory in human medial temporal lobe.

Kyle F Shattuck, John W VanMeter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kyle F ShattuckDepartment of Neuroscience, Georgetown University Medical Center, Washington, D.C., USA.
John W VanMeterDepartment of Neurology, Georgetown University Medical Center, Washington, D.C., USA.

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUKL2RR031974 · NCRR · GEORGETOWN UNIVERSITY · PI VERBALIS, JOSEPH G · 2010 to 2011
$711k
NCRR NIH HHS KL2 RR031974NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

purposeTo detect local cholinergic changes in human medial temporal lobe during configural working memory performance. MATERIALS AND

methodsProton magnetic resonance spectroscopy (

resultsIncreases from a resting baseline in the Cho/Cre ratio were observed during 60-second blocks of active memory maintenance across the group (P = 0.0042). Behavioral accuracy during task performance correlated with memory retention (r = 0.48, P = 0.027). Quality assurance measures showed task-based changes in Cre resonance signal both individually (P = 0.00099) and when utilized as a noncholinergic internal reference (NAA/Cre, P = 0.00079).

conclusionIncreases in human medial temporal lobe LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:682-691.

Indexed as

AdolescentAdultFemaleHumansMaleMemory, Short-TermProton Magnetic Resonance SpectroscopyTask Performance and AnalysisTemporal LobeYoung Adultacetylcholinecholinecreatinemagnetic resonance spectroscopymedial temporal lobeworking memory

Identifiers

PMID28699178
PMCPMC5775056

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.