ReviewMolecular biotechnology2017
Genetically Modified Pigs as Organ Donors for Xenotransplantation.
Review in Molecular biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- The xenotransplantation hybrid hospital: structural, economic, and regulatory frameworks for zero-ischemia clinical translation.Clinical transplantation and research · 2026Review
- Future of xenotransplantation in Korea.Clinical transplantation and research · 2026Review
- Porcine kidney xenotransplantation: From primate models to clinical reality.Animal models and experimental medicine · 2026Review
- Alpha-gal xenoantigens in bioprosthetic valve recipients: clinical implications for bioprosthesis longevity.Journal of cardiothoracic surgery · 2026Review
- Liver Xenotransplantation: From Early Primate Trials to the First-in-Human Porcine Bridging Therapies.Journal of clinical medicine · 2026Review
- Structural and functional comparative analysis of porcine and human salivary glands: a narrative review for translational research.Journal of molecular histology · 2026Review
- Galangin Regulates Oxidative Stress Levels in Porcine Embryos Through Interaction with the Neh1 Domain of Nrf2.Antioxidants (Basel, Switzerland) · 2025Article
- Interleukin-7 promotes porcine early embryogenesis in vitro and inner cell mass development through PI3K/AKT pathway after parthenogenetic activation.Scientific reports · 2025Article
- Natural biomaterials in the management of the aortic valve pathology. Biomedical and clinical aspects: A review.Biomolecules & biomedicine · 2025Review
- Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling.Clinical and translational medicine · 2025Article
- The pig as a medical model for gynecological diseases: an applied perspective.Frontiers in veterinary science · 2025Review
- Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies.Frontiers in immunology · 2025Review
- Xenotransplantation could either be a friend or foe of healthcare equity.Communications medicine · 2024Article
- Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage.Journal of translational medicine · 2024Review
- Single-cell transcriptomic analysis reveals transcriptional and cell subpopulation differences between human and pig immune cells.Genes & genomics · 2024Article
- Comparative analysis of swine leukocyte antigen gene diversity in Göttingen Minipigs.Frontiers in immunology · 2024Article
- Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys.Frontiers in immunology · 2024Article
- Liver Xenotransplantation: A Path to Clinical Reality.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Cutting edge of genetically modified pigs targeting complement activation for xenotransplantation.Frontiers in immunology · 2024Review
- The progress of induced pluripotent stem cells derived from pigs: a mini review of recent advances.Frontiers in cell and developmental biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The growing shortage of available organs is a major problem in transplantology. Thus, new and alternative sources of organs need to be found. One promising solution could be xenotransplantation, i.e., the use of animal cells, tissues and organs. The domestic pig is the optimum donor for such transplants. However, xenogeneic transplantation from pigs to humans involves high immune incompatibility and a complex rejection process. The rapid development of genetic engineering techniques enables genome modifications in pigs that reduce the cross-species immune barrier.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.