Evidence map›Paper›PMID 28698925›Full record

ArticleInternational archives of occupational and environmental health2017

Prolonged perceived stress and saliva cortisol in a large cohort of Danish public service employees: cross-sectional and longitudinal associations.

Sigurd Mikkelsen, Julie Lyng Forman, Samuel Fink, Marianne Agergaard Vammen, Jane Frølund Thomsen, Matias Brødsgaard Grynderup, Åse Marie Hansen, Linda Kaerlev, Henrik Albert Kolstad, Reiner Rugulies and 1 more

Abstract read
In one paragraph

Article in International archives of occupational and environmental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Association between burnout and immunological and endocrine alterations.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sigurd MikkelsenDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark. sigurd.mikkelsen.01@regionh.dk.
Julie Lyng FormanSection of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Samuel FinkDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Marianne Agergaard VammenDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Jane Frølund ThomsenDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Matias Brødsgaard GrynderupDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Åse Marie HansenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Linda KaerlevResearch Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Henrik Albert KolstadDepartment of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Århus, Denmark.
Reiner RuguliesDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jens Peter BondeDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIt is well known that acute stress can lead to a transient increase in cortisol secretion, but the effects of prolonged stress on cortisol secretion are uncertain. This study examines the cross-sectional and longitudinal associations between prolonged perceived stress and salivary cortisol.

methodsIn 2007, 4467 Danish public service employees participated in a study of stress and mental health, and 3217 participated in a follow-up in 2009. Perceived stress during the past 4 weeks was assessed by Cohen's four item perceived stress scale. Participants were asked to collect saliva 30 min after awakening and at approximately 20:00 in the evening. The cortisol dependence on perceived stress was examined in regression analyses adjusted for effects of potential confounders. We adjusted for a large variation in saliva sampling times by modelling the time trajectory of cortisol concentrations in the morning and in the evening and examined if they were influenced by perceived stress.

resultsPerceived stress had no statistically significant effects on the level or time trajectory of morning or evening cortisol, neither cross-sectionally nor longitudinally. The 1 month prevalence of frequently perceived stress was low, approximately 2.5%.

conclusionOur results did not support the hypothesis that prolonged perceived stress is associated with the level or time trajectory of morning or evening salivary cortisol.

Indexed as

AdultAgedCircadian RhythmCross-Sectional StudiesDenmarkFemaleHumansHydrocortisoneLongitudinal StudiesMaleMiddle AgedSalivaStress, PsychologicalHydrocortisoneChronic stressCohen’s perceived stress scaleDiurnal cortisolEpidemiologyOccupational healthPRISME study

Identifiers

PMID28698925
PMCPMC5640736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.