Evidence map›Paper›PMID 28698872›Full record

ArticleBioMed research international2017

Proliferation of Interstitial Cells in the Cyclophosphamide-Induced Cystitis and the Preventive Effect of Imatinib.

Maria Sancho, Domingo Triguero, Aranzazu Lafuente-Sanchis, Angeles Garcia-Pascual

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Precision-Cut Bladder Slices: A Novel Model for the Study of Bladder Fibrosis and Potential Anti-Fibrotic Agents.International journal of urology : official journal of the Japanese Urological Association · 2026
    Article
  2. Article
  3. Defining the molecular fingerprint of bladder and kidney fibroblasts.American journal of physiology. Renal physiology · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Maria SanchoDepartment of Physiology, School of Veterinary Medicine, Complutense University, Madrid, Spain.ORCID 0000-0003-4750-1040
Domingo TrigueroDepartment of Physiology, School of Veterinary Medicine, Complutense University, Madrid, Spain.ORCID 0000-0002-5273-6453
Aranzazu Lafuente-SanchisDepartment of Physiology, School of Veterinary Medicine, Complutense University, Madrid, Spain.
Angeles Garcia-PascualDepartment of Physiology, School of Veterinary Medicine, Complutense University, Madrid, Spain.ORCID 0000-0001-9706-2125
Universidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclophosphamide- (CYP-) induced cystitis in the rat is a well-known model of bladder inflammation that leads to an overactive bladder, a process that appears to involve enhanced nitric oxide (NO) production. We investigated the changes in the number and distribution of interstitial cells (ICs) and in the expression of endothelial NO synthase (eNOS) in the bladder and urethra of rats subjected to either intermediate or chronic CYP treatment. Pronounced hyperplasia and hypertrophy of ICs were evident within the lamina propria and in the muscle layer. IC immunolabeling with CD34, PDGFR

Indexed as

Cystitis, InterstitialAnimalsAntigens, CD34Cell ProliferationCyclophosphamideDisease Models, AnimalFemaleImatinib MesylateNitric OxideNitric Oxide Synthase Type IIIRatsRats, WistarReceptor, Platelet-Derived Growth Factor alphaAntigens, CD34CyclophosphamideImatinib MesylateNitric OxideNitric Oxide Synthase Type IIINos3 protein, ratReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID28698872
PMCPMC5494099
OpenAlexW2625040354

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.