ReviewNeural plasticity2017
Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions.
Review in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.Neurobiology of disease · 2026Article
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.bioRxiv : the preprint server for biology · 2025Article
- mWAKE in the Central Amygdala Regulates Fear Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Tracking conditioned fear in pair-housed mice using deep learning and real-time cue delivery.Neurobiology of stress · 2025Article
- How chronotype, sleep-wake cycle, subjective time experience influence retrospective, and prospective memory functioning.Frontiers in cognition · 2025Article
- Differential Expression of Circadian Clock Genes in the Bovine Neuroendocrine Adrenal System.Genes · 2023Article
- From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase.Journal of lipid research · 2023Article
- Emotionally clocked out: cell-type specific regulation of mood and anxiety by the circadian clock system in the brain.Frontiers in molecular neuroscience · 2023Review
- Time to learn: The role of the molecular circadian clock in learning and memory.Neurobiology of learning and memory · 2022Review
- Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats.Frontiers in molecular neuroscience · 2022Article
- Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction.Neurobiology of stress · 2020Article
- The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2020Review
- Potential Pathways for Circadian Dysfunction and Sundowning-Related Behavioral Aggression in Alzheimer's Disease and Related Dementias.Frontiers in neuroscience · 2020Review
- Sex and Time-of-Day Impact on Anxiety and Passive Avoidance Memory Strategies in Mice.Frontiers in behavioral neuroscience · 2020Article
- Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation.Nature communications · 2019Article
- Microtopography of fear memory consolidation and extinction retrieval within prefrontal cortex and amygdala.Psychopharmacology · 2019Article
- Midday meals do not impair mouse memory.Scientific reports · 2018Article
- A hypothalamic circuit for the circadian control of aggression.Nature neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of fear memories is a powerful and highly evolutionary conserved mechanism that serves the behavioral adaptation to environmental threats. Accordingly, classical fear conditioning paradigms have been employed to investigate fundamental molecular processes of memory formation. Evidence suggests that a circadian regulation mechanism allows for a timestamping of such fear memories and controlling memory salience during both their acquisition and their modification after retrieval. These mechanisms include an expression of molecular clocks in neurons of the amygdala, hippocampus, and medial prefrontal cortex and their tight interaction with the intracellular signaling pathways that mediate neural plasticity and information storage. The cellular activities are coordinated across different brain regions and neural circuits through the release of glucocorticoids and neuromodulators such as acetylcholine, which integrate circadian and memory-related activation. Disturbance of this interplay by circadian phase shifts or traumatic experience appears to be an important factor in the development of stress-related psychopathology, considering these circadian components are of critical importance for optimizing therapeutic approaches to these disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.