Evidence map›Paper›PMID 28698795›Full record

ArticleF1000Research2015

Semi-automated Modular Program Constructor for physiological modeling: Building cell and organ models.

Bartholomew Jardine, Gary M Raymond, James B Bassingthwaighte

Abstract read
In one paragraph

Article in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bartholomew JardineDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
Gary M RaymondDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
James B BassingthwaighteDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.

Funding

3D IMAGING &COMPUTER MODEL OF THE RESPIRATORY TRACTR01HL073598 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI CORLEY, RICHARD A · 2004 to 2014
$17.6M
The Virtual Physiological Rat ProjectP50GM094503 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2011 to 2015
$11.6M
Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demandU01HL122199 · NHLBI · UNIVERSITY OF WASHINGTON · PI BEARD, DANIEL A, DASH, RANJAN K · 2015 to 2019
$3.3M
Modeling for Heart, Lung, and Blood: From Cell to OrganT15HL088516 · NHLBI · UNIVERSITY OF WASHINGTON · PI BASSINGTHWAIGHTE, JAMES B · 2007 to 2010
$929k
NHLBI NIH HHS R01 HL073598NHLBI NIH HHS T15 HL088516NHLBI NIH HHS U01 HL122199NIGMS NIH HHS P50 GM094503
6 · The paper itself

Abstract

The Modular Program Constructor (MPC) is an open-source Java based modeling utility, built upon JSim's Mathematical Modeling Language (MML) ( http://www.physiome.org/jsim/) that uses directives embedded in model code to construct larger, more complicated models quickly and with less error than manually combining models. A major obstacle in writing complex models for physiological processes is the large amount of time it takes to model the myriad processes taking place simultaneously in cells, tissues, and organs. MPC replaces this task with code-generating algorithms that take model code from several different existing models and produce model code for a new JSim model. This is particularly useful during multi-scale model development where many variants are to be configured and tested against data. MPC encodes and preserves information about how a model is built from its simpler model modules, allowing the researcher to quickly substitute or update modules for hypothesis testing. MPC is implemented in Java and requires JSim to use its output. MPC source code and documentation are available at http://www.physiome.org/software/MPC/.

Indexed as

JSimmulti-scale modelingphysiological modelingreproducibilitysystems biologyuncertainty quantification

Identifiers

PMID28698795
PMCPMC5488124

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.