Evidence map›Paper›PMID 28698673›Full record

ArticleThe Journal of antibiotics2017

A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.

Dhanalakshmi R Nair, Ji Chen, João M Monteiro, Michaele Josten, Mariana G Pinho, Hans-Georg Sahl, Jimmy Wu, Ambrose Cheung

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antibiotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Dhanalakshmi R NairDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Ji ChenDepartment of Chemistry, Dartmouth College, Hanover, NH, USA.
João M MonteiroBacterial Cell Biology Laboratory, Instituto de Technologia Química e Biológica, Universidade Nova de Lisboa, Avenida da República (EAN), Oeiras, Portugal.
Michaele JostenPharmaceutical Microbiology Section, Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany.
Mariana G PinhoBacterial Cell Biology Laboratory, Instituto de Technologia Química e Biológica, Universidade Nova de Lisboa, Avenida da República (EAN), Oeiras, Portugal.
Hans-Georg SahlPharmaceutical Microbiology Section, Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany.
Jimmy WuDepartment of Chemistry, Dartmouth College, Hanover, NH, USA.
Ambrose CheungDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Dartmouth College · USUniversidade Nova de Lisboa · PTUniversity of Bonn · DE

Funding

Treatments for Nipah Virus InfectionU54AI057159 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WHELAN, SEAN PJ · 2003 to 2013
$113.7M
TRANSLATIONAL RESEARCH COREP30GM106394 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2013 to 2017
$6.1M
European Research Council 310987NIAID NIH HHS U54 AI057159NIGMS NIH HHS P30 GM106394
6 · The paper itself

Abstract

In a loss-of-viability screen of small molecules against methicillin-resistant Staphylococcus aureus (MRSA) USA300, we found a small molecule, designated DNAC-2, which has an MIC of 8 μg ml

Indexed as

AnaerobiosisAnti-Bacterial AgentsCell MembraneCell WallFermentationHydroxyquinolinesMembrane PotentialsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicrobial ViabilityMicroscopy, Electron, TransmissionTime FactorsAnti-Bacterial AgentsHydroxyquinolines

Identifiers

PMID28698673
PMCPMC5621627
OpenAlexW2735638808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.