ArticleScientific reports2017
Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers.
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Who cites it
221 citing papers in PubMed.
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- Salience Network Dynamics Across Spontaneous Attacks, Interictal Rest and Interictal Pain Imagery in Menstrually Related Migraine.Brain topography · 2026Article
- Dynamic Repertoire of Brain Networks in Mindfulness-Based Cognitive Therapy During Rumination: A Randomized Controlled Trial.Biological psychiatry global open science · 2026Article
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in post-COVID-19 syndrome.Brain, behavior, & immunity - health · 2026Article
- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
- Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy.Nature communications · 2026Article
- Cognitive-Behavioral Predictors of Individual Variability of Functional Connectivity in Healthy Young Adults.Research square · 2026Article
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Energy-Based Phase-Locking State Analysis in Brain State Identification.Human brain mapping · 2026Article
- Large-scale brain dynamics are organized by a directional coordination hierarchy.bioRxiv : the preprint server for biology · 2026Article
- Robust Multi-Site ADHD Classification via GraphSAGE-Based Functional Connectivity Modeling from rs-fMRI.Bioengineering (Basel, Switzerland) · 2026Article
- Tract-explainable and underexplained synchrony play complementary roles in the functional organization of the brain.bioRxiv : the preprint server for biology · 2026Article
- Neuromodulation-induced normalization of cortical metastable dynamics signatures in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Hypercapnia dissociates neuronal and hemodynamic responses impairing neurovascular coupling and functional brain connectivity.Nature communications · 2026Article
- Effects of Age on Resting-State Cortical Networks.Human brain mapping · 2026Article
- System identification and surrogate data analyses imply approximate Gaussianity and non-stationarity of resting-brain dynamics.bioRxiv : the preprint server for biology · 2026Article
161 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns - or states - are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.
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