Evidence map›Paper›PMID 28698610›Full record

ArticleScientific reports2017

Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations.

Jessica L Cooperstone, Kathleen L Tober, Ken M Riedl, Matthew D Teegarden, Morgan J Cichon, David M Francis, Steven J Schwartz, Tatiana M Oberyszyn

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Article
  3. Phytoconstituents in photoaging: therapeutic potential in prevention and regeneration.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
  4. Article
  5. Skin Protection by Carotenoid Pigments.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Lycopene from Red Guava (Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Role of Phytochemicals in Skin PhotoprotectionFrontiers in pharmacology · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica L CooperstoneDepartment of Food Science and Technology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-7920-0088
Kathleen L ToberDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ken M RiedlDepartment of Food Science and Technology, The Ohio State University, Columbus, OH, USA.
Matthew D TeegardenDepartment of Food Science and Technology, The Ohio State University, Columbus, OH, USA.
Morgan J CichonDepartment of Food Science and Technology, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-9379-0264
David M FrancisDepartment of Horticulture and Crop Sciences, The Ohio State University, Wooster, OH, USA.
Steven J SchwartzDepartment of Food Science and Technology, The Ohio State University, Columbus, OH, USA.
Tatiana M OberyszynDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. tatiana.oberyszyn@osumc.edu.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Carotenoids as protectors against UVB induced cutaneous damage.R21CA158625 · NCI · OHIO STATE UNIVERSITY · PI OBERYSZYN, TATIANA M · 2012 to 2013
$355k
NCI NIH HHS P30 CA016058NCI NIH HHS R21 CA158625
6 · The paper itself

Abstract

Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11-20, mice (n = 120) were exposed to 2240 J/m

Indexed as

AnimalsBiological ProductsCarotenoidsChromatography, High Pressure LiquidDisease Models, AnimalLycopeneMaleMetabolomicsMicePlant ExtractsSkin NeoplasmsSolanum lycopersicumTandem Mass SpectrometryUltraviolet RaysBiological ProductsCarotenoidsLycopenePlant Extracts

Identifiers

PMID28698610
PMCPMC5506060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.