ArticleScientific reports2017
Injectable hybrid system for strontium local delivery promotes bone regeneration in a rat critical-sized defect model.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Anti-miR-195-engineered mesenchymal stem cells promote migration, vascularization, and ECM protein expression in vivo.Stem cell research & therapy · 2026Article
- A Systematic Review of Metal Composite Bone Grafts in Preclinical Spinal Fusion Models.Biomimetics (Basel, Switzerland) · 2025Review
- Composite or Modified Hydroxyapatite Microspheres as Drug Delivery Carrier for Bone and Tooth Tissue Engineering.Current medicinal chemistry · 2025Review
- T. gondii excretory proteins promote the osteogenic differentiation of human bone mesenchymal stem cells via the BMP/Smad signaling pathway.Journal of orthopaedic surgery and research · 2024Article
- Biomimetic Hydrogel Applications and Challenges in Bone, Cartilage, and Nerve Repair.Pharmaceutics · 2023Review
- Article
- Transcriptome Analysis Revealed the Symbiosis Niche of 3D Scaffolds to Accelerate Bone Defect Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View.Materials (Basel, Switzerland) · 2022Review
- Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation.Frontiers in bioengineering and biotechnology · 2022Review
- Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery.Gels (Basel, Switzerland) · 2021Review
- Characterization of Sodium Alginate Hydrogels Reinforced with Nanoparticles of Hydroxyapatite for Biomedical Applications.Polymers · 2021Article
- The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment.International journal of molecular sciences · 2021Review
- Recent developments in strontium-based biocomposites for bone regeneration.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2020Review
- Functionality-packed additively manufactured porous titanium implants.Materials today. Bio · 2020Article
- A review of the latest insights into the mechanism of action of strontium in bone.Bone reports · 2020Review
- Modular microcarrier technologies for cell-based bone regeneration.Journal of materials chemistry. B · 2020Review
- Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches.Pharmaceutics · 2020Review
- Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction.Frontiers in cell and developmental biology · 2020Review
- Article
- Applications of alginate microspheres in therapeutics delivery and cell culture: Past, present and future.International journal of pharmaceutics · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strontium (Sr) has been described as having beneficial influence in bone strength and architecture. However, negative systemic effects have been reported on oral administration of Sr ranelate, leading to strict restrictions in clinical application. We hypothesized that local delivery of Sr improves osteogenesis without eliciting detrimental side effects. Therefore, the in vivo response to an injectable Sr-hybrid system composed of RGD-alginate hydrogel cross-linked in situ with Sr and reinforced with Sr-doped hydroxyapatite microspheres, was investigated. The system was injected in a critical-sized bone defect model and compared to a similar Sr-free material. Micro-CT results show a trend towards higher new bone formed in Sr-hybrid group and major histological differences were observed between groups. Higher cell invasion was detected at the center of the defect of Sr-hybrid group after 15 days with earlier bone formation. Higher material degradation with increase of collagen fibers and bone formation in the center of the defect after 60 days was observed as opposed to bone formation restricted to the periphery of the defect in the control. These histological findings support the evidence of an improved response with the Sr enriched material. Importantly, no alterations were observed in the Sr levels in systemic organs or serum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.