ArticleScientific reports2017
SmMYB36, a Novel R2R3-MYB Transcription Factor, Enhances Tanshinone Accumulation and Decreases Phenolic Acid Content in Salvia miltiorrhiza Hairy Roots.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed, 154 citations in OpenAlex.
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- A novel synergistic regulatory mechanism involving the MYB39-MYB111-bHLH51-TTG1 module in the phenolic and diterpenoid biosynthetic pathways of Salvia miltiorrhiza.Plant biotechnology journal · 2025Article
- Glycyrrhiza, a commonly used medicinal herb: Review of species classification, pharmacology, active ingredient biosynthesis, and synthetic biology.Journal of advanced research · 2025Review
- The PlMYB73-PlMYB70-PlMYB108 complex regulatesHorticulture research · 2025Article
- Metabolomic and Transcriptomic Analyses Reveal Changes in Active Components During the Growth and Development of Comfrey (Plants (Basel, Switzerland) · 2025Article
- Genome-wide comprehensive analysis the molecular phylogenetic evolution, functional divergence and tissue-specific expression ofFrontiers in plant science · 2025Article
- MAPK3-MYB36-ARF1 module regulates the tanshinone formation inPlant signaling & behavior · 2024Article
- Genome-wide association mapping of biochemical traits and its correlation with MYMIV resistance in mungbean (Vigna radiata L. Wilczek).Scientific reports · 2024Article
- The Smi-miR858a-Horticulture research · 2024Article
- Transcriptomic Analyses Reveal Insights into the Shared Regulatory Network of Phenolic Compounds and Steviol Glycosides inInternational journal of molecular sciences · 2024Article
- Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.Chinese medicine · 2024Article
- Transcriptome and volatile compounds analyses of floral development provide insight into floral scent formation inFrontiers in plant science · 2024Article
- Effect of interfering TOR signaling pathway on the biosynthesis of terpenoids inPlant signaling & behavior · 2023Article
- Establishment and validation of a callus tissue transformation system for German chamomile (Matricaria chamomilla L.).BMC plant biology · 2023Article
- Simultaneous Promotion of Salt Tolerance and Phenolic Acid Biosynthesis inInternational journal of molecular sciences · 2023Article
- Analysis ofInternational journal of molecular sciences · 2023Article
- Advances in the Biosynthesis of Terpenoids and Their Ecological Functions in Plant Resistance.International journal of molecular sciences · 2023Review
- Lavandula Species, Their Bioactive Phytochemicals, and Their Biosynthetic Regulation.International journal of molecular sciences · 2023Review
- The Blinin Accumulation Promoted by CbMYB32 Involved inInternational journal of molecular sciences · 2023Article
6 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 1 country.
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Abstract
Phenolic acids and tanshinones are two major bioactive components in Salvia miltiorrhiza Bunge. A novel endogenous R2R3-MYB transcription factor, SmMYB36, was identified in this research. This transcript factor can simultaneously influence the content of two types of components in SmMYB36 overexpression hairy roots. SmMYB36 was mainly localized in the nucleus of onion epidermis and it has transactivation activity. The overexpression of SmMYB36 promoted tanshinone accumulation but inhibited phenolic acid and flavonoid biosynthesis in Salvia miltiorrhiza hairy roots. The altered metabolite content was due to changed metabolic flow which was regulated by transcript expression of metabolic pathway genes. The gene transcription levels of the phenylpropanoid general pathway, tyrosine derived pathway, methylerythritol phosphate pathway and downstream tanshinone biosynthetic pathway changed significantly due to the overexpression of SmMYB36. The wide distribution of MYB binding elements (MBS, MRE, MBSI and MBSII) and electrophoretic mobility shift assay results indicated that SmMYB36 may be an effective tool to regulate metabolic flux shifts.
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