ArticleProceedings of the National Academy of Sciences of the United States of America2017
Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Spatial biases in visual feature representation of mouse dorsal lateral geniculate nucleus boutons.iScience · 2026Article
- Convergence of Cortical and Thalamic Origins of Free Behavior Modulation of Mouse Primary Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Effects of corticothalamic feedback depend on visual responsiveness and stimulus type.iScience · 2025Article
- Differential Impact of Retinal Lesions on Visual Responses of LGN X and Y Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore.Nature communications · 2025Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Origin of visual experience-dependent theta oscillations.Current biology : CB · 2025Article
- Local stimulation of pyramidal neurons in deep cortical layers of anesthetized rats enhances cortical visual information processing.Scientific reports · 2024Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Parallel Streams of Direct Corticogeniculate Feedback from Mid-level Extrastriate Cortex in the Macaque Monkey.eNeuro · 2024Article
- Rapid adaptation of primate LGN neurons to drifting grating stimulation.Journal of neurophysiology · 2023Article
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- Functional ultrasound imaging reveals 3D structure of orientation domains in ferret primary visual cortex.NeuroImage · 2023Article
- The dorsal lateral geniculate nucleus and the pulvinar as essential partners for visual cortical functions.Frontiers in neuroscience · 2023Review
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Corticothalamic feedback sculpts visual spatial integration in mouse thalamus.Nature neuroscience · 2021Article
- Morphological evidence for multiple distinct channels of corticogeniculate feedback originating in mid-level extrastriate visual areas of the ferret.Brain structure & function · 2021Article
- Rapid and Bihemispheric Reorganization of Neuronal Activity in Premotor Cortex after Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Delineating the organization of projection neuron subsets in primary visual cortex with multiple fluorescent rabies virus tracing.Brain structure & function · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The corticogeniculate (CG) pathway connects the visual cortex with the visual thalamus (LGN) in the feedback direction and enables the cortex to directly influence its own input. Despite numerous investigations, the role of this feedback circuit in visual perception remained elusive. To probe the function of CG feedback in a causal manner, we selectively and reversibly manipulated the activity of CG neurons in anesthetized ferrets in vivo using a combined viral-infection and optogenetics approach to drive expression of channelrhodopsin2 (ChR2) in CG neurons. We observed significant increases in temporal precision and spatial resolution of LGN neuronal responses to drifting grating and white noise stimuli when CG neurons expressing ChR2 were light activated. Enhancing CG feedback reduced visually evoked response latencies, increased spike-timing precision, and reduced classical receptive field size. Increased precision among LGN neurons led to increased spike-timing precision among granular layer V1 neurons as well. Together, our findings suggest that the function of CG feedback is to control the timing and precision of thalamic responses to incoming visual signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.