Evidence map›Paper›PMID 28698302›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2017

Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds.

Hsia-Lien Lin, Haoming Zhang, Vyvyca J Walker, Jaime D'Agostino, Paul F Hollenberg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.International journal of molecular sciences · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hsia-Lien LinDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan.
Haoming ZhangDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan.
Vyvyca J WalkerDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan.
Jaime D'AgostinoDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan.
Paul F HollenbergDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan phollen@umich.edu.
University of Michigan–Ann Arbor · US

Funding

ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
HEMOPROTEIN-CATALYZED OXYGENATIONS OF CARCINOGENSR01CA016954 · NCI · WAYNE STATE UNIVERSITY · PI HOLLENBERG, PAUL F. · 1986 to 2011
$4.3M
NCI NIH HHS R01 CA016954NIEHS NIH HHS T32 ES007062
6 · The paper itself

Abstract

The mechanism-based inactivation of human CYP2J2 by three terminal acetylenic compounds:

Indexed as

AlkynesAmidesButyrophenonesChromatography, LiquidCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDanazolEnzyme ActivationFatty Acids, UnsaturatedHemeHumansKineticsPiperidinesTandem Mass Spectrometry17-octadecynoic acidAlkynesAmidesButyrophenonesCYP2J2 protein, humanCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDanazolFatty Acids, UnsaturatedHemehydroxyebastineN-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamidePiperidines

Identifiers

PMID28698302
PMCPMC5539586
OpenAlexW2734668435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.