Evidence map›Paper›PMID 28698282›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men.

Katya B Rubinow, Jing H Chao, Derek Hagman, Mario Kratz, Brian Van Yserloo, Nilesh W Gaikwad, John K Amory, Stephanie T Page

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Katya B RubinowCenter for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington; rubinow@uw.edu.ORCID 0000-0002-6505-5657
Jing H ChaoCenter for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
Derek HagmanThe Fred Hutchinson Cancer Research Center, Seattle, Washington; and.
Mario KratzDepartment of Nutrition and Department of Environmental Toxicology, University of California-Davis, Davis, California.
Brian Van YserlooDepartment of Surgery, University of Washington School of Medicine, Seattle, Washington.
Nilesh W GaikwadDepartment of Nutrition and Department of Environmental Toxicology, University of California-Davis, Davis, California.
John K AmoryCenter for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
Stephanie T PageCenter for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
University of Washington · USUniversity of California, Davis · USFred Hutch Cancer Center · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Tomas Vaisar · 1986 to 2026
$41.4M
Spermatogonial Stem Cell Self-Renewal and DifferentiationU54HD042454 · NICHD · UNIVERSITY OF WASHINGTON · PI BREMNER, WILLIAM J · 2002 to 2016
$26.9M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Men's Reproductive Health Research at the Univ of WashingtonK12HD053984 · NICHD · UNIVERSITY OF WASHINGTON · PI BREMNER, WILLIAM J · 2006 to 2016
$2.9M
Dose-response relationships between circulating and intraprostatic androgens in mR01AG037603 · NIA · UNIVERSITY OF WASHINGTON · PI PAGE, STEPHANIE T · 2010 to 2014
$1.6M
Retinoic Acid in Male InfertilityK24HD082231 · NICHD · UNIVERSITY OF WASHINGTON · PI AMORY, JOHN K. · 2015 to 2019
$638k
NIA NIH HHS R01 AG037603NICHD NIH HHS K12 HD053984NIDDK NIH HHS P30 DK017047NIDDK NIH HHS T32 DK007247
6 · The paper itself

Abstract

Male hypogonadism results in changes in body composition characterized by increases in fat mass. Resident immune cells influence energy metabolism in adipose tissue and could promote increased adiposity through paracrine effects. We hypothesized that manipulation of circulating sex steroid levels in healthy men would alter adipose tissue immune cell populations. Subjects (

Indexed as

Adipose TissueAdultAromatase InhibitorsCD11c AntigenCD3 ComplexCD4 AntigensEstradiolGene Expression RegulationGonadal Steroid HormonesHealthy VolunteersHumansImmunity, CellularMaleMiddle AgedReceptors, LHRHTestosteroneAromatase InhibitorsCD11c AntigenCD3 ComplexCD4 AntigensEstradiolGNRHR protein, humanGonadal Steroid HormonesReceptors, LHRHTestosteroneadipose tissueestrogenimmune cellsobesitytestosterone

Identifiers

PMID28698282
PMCPMC5792144
OpenAlexW2736246487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.