Evidence map›Paper›PMID 28698279›Full record

ArticlemBio2017

Zika Virus Persistently Infects and Is Basolaterally Released from Primary Human Brain Microvascular Endothelial Cells.

Megan C Mladinich, John Schwedes, Erich R Mackow

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 129 citations in OpenAlex.

  1. Review
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  14. An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Zika Virus Neuropathogenesis-Research and Understanding.Pathogens (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Megan C MladinichDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
John SchwedesGenomics Core Facility, Stony Brook University, Stony Brook, New York, USA.
Erich R MackowDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA Erich.Mackow@stonybrook.edu.
Stony Brook University · US

Funding

MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
Defining ANDV Virulence and Attenuation MechanismsR01AI129010 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2017 to 2021
$2.8M
Therapeutic Interventions Against ANDV Induced PathogenesisR01AI093792 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2012 to 2016
$2.2M
Novel Hantavirus Virulence DeterminantsR56AI119854 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2016 to 2016
$666k
Role of Persistent Zika Virus Infection of Endothelial Cells in PathogenesisR21AI131729 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2017 to 2018
$432k
NIAID NIH HHS R01 AI093792NIAID NIH HHS R01 AI129010NIAID NIH HHS R21 AI131729NIAID NIH HHS R56 AI119854NIAID NIH HHS T32 AI007539
6 · The paper itself

Abstract

Zika virus (ZIKV) is a mosquito-borne

Indexed as

Virus ReleaseVirus ReplicationAntiviral AgentsBrainCells, CulturedChemokine CCL5EndopeptidasesEndothelial CellsGene Expression ProfilingHumansImmunity, InnateInterferon-alphaInterferon-betaInterferon Regulatory Factor-7Interferon-Stimulated Gene Factor 3, gamma SubunitIntracellular Signaling Peptides and ProteinsAntiviral AgentsCCL5 protein, humanChemokine CCL5EndopeptidasesHERC5 protein, humanInterferon-alphaInterferon-betaInterferon Regulatory Factor-7Interferon-Stimulated Gene Factor 3, gamma SubunitIntracellular Signaling Peptides and ProteinsIRF7 protein, humanIRF9 protein, humanUbiquitin ThiolesteraseUSP18 protein, humanbasolateral releasecell survivalchemokine CCL5human brain endothelial cellsIFN-β regulationinnate immune regulationISG15 inductionpersistent infectiontranscriptome analysisZika virus

Identifiers

PMID28698279
PMCPMC5513708
OpenAlexW2735214245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.