ArticlemBio2017
On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires.
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Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- CRISPR rewired: from adaptive immunity to a global virulence control network in Salmonella.World journal of microbiology & biotechnology · 2026Review
- Evolutionary interplay between viruses and R-loops.FEBS letters · 2025Review
- Antiviral reverse transcriptases reveal the evolutionary origin of telomerase.bioRxiv : the preprint server for biology · 2025Article
- Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis.Biotechnology and bioengineering · 2025Article
- Adaptive immunity of type VI CRISPR-Cas systems associated with reverse transcriptase-Cas1 fusion proteins.Nucleic acids research · 2024Article
- Mechanisms used for cDNA synthesis and site-specific integration of RNA into DNA genomes by a reverse transcriptase-Cas1 fusion protein.Science advances · 2024Article
- RNAVirHost: a machine learning-based method for predicting hosts of RNA viruses through viral genomes.GigaScience · 2024Article
- Harnessing CRISPR-Cas adaptation for RNA recording and beyond.BMB reports · 2024Review
- Mechanisms used for cDNA synthesis and site-specific integration of RNA into DNA genomes by a reverse transcriptase-Cas1 fusion protein.bioRxiv : the preprint server for biology · 2023Article
- Reverse transcriptases prime DNA synthesis.Nucleic acids research · 2023Article
- Structural biology of CRISPR-Cas immunity and genome editing enzymes.Nature reviews. Microbiology · 2022Review
- Identification and classification of reverse transcriptases in bacterial genomes and metagenomes.Nucleic acids research · 2022Article
- Different modes of spacer acquisition by the Staphylococcus epidermidis type III-A CRISPR-Cas system.Nucleic acids research · 2022Article
- Global phylogenomic novelty of the Cas1 gene from hot spring microbial communities.Frontiers in microbiology · 2022Article
- Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions.Frontiers in microbiology · 2022Review
- Recruitment of Mobile Genetic Elements for Diverse Cellular Functions in Prokaryotes.Frontiers in molecular biosciences · 2022Review
- Evolutionary plasticity and functional versatility of CRISPR systems.PLoS biology · 2022Article
- Prokaryotic reverse transcriptases: from retroelements to specialized defense systems.FEMS microbiology reviews · 2021Review
- Type III CRISPR-Cas Systems: Deciphering the Most Complex Prokaryotic Immune System.Biochemistry. Biokhimiia · 2021Review
- Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 10 institutions in 3 countries.
Sukrit SilasDepartments of Pathology and Genetics, Stanford University, Stanford, California, USA.
Kira S MakarovaNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Sergey ShmakovNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
David Páez-EspinoDepartment of Energy, Joint Genome Institute, Walnut Creek, California, USA.
Georg MohrDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, USA.
Yi LiuDepartment of Biomedical Informatics, Stanford University, Stanford, California, USA.
Michelle DavisonDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California, USA.
Simon RouxDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Siddharth R KrishnamurthyDepartments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Becky Xu Hua FuDepartments of Pathology and Genetics, Stanford University, Stanford, California, USA.
Loren L HansenDepartments of Pathology and Genetics, Stanford University, Stanford, California, USA.
David WangDepartments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Matthew B SullivanDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Andrew MillardMicrobiology and Infection Unit, Warwick Medical School, University of Warwick, Warwick, United Kingdom.
Martha R ClokieDepartment Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Devaki BhayaDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California, USA.
Alan M LambowitzDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, USA.
Nikos C KyrpidesDepartment of Energy, Joint Genome Institute, Walnut Creek, California, USA.
Eugene V KooninNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-3943-8299
Andrew Z FireDepartments of Pathology and Genetics, Stanford University, Stanford, California, USA afire@stanford.edu.
Stanford University · USCarnegie Institution for Science · USJoint Genome Institute · USNational Institutes of Health · USThe Ohio State University · USThe University of Texas at Austin · USWashington University in St. Louis · USSkolkovo Institute of Science and Technology · RUUniversity of Leicester · GBUniversity of Warwick · GB
Funding
GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8MGENE REGULATION DURING EARLY DEVELOPMENT OF C. ELEGANSR01GM037706 · NIGMS · STANFORD UNIVERSITY · PI FIRE, ANDREW Z. · 1987 to 2018
$11.0MRETROPLASMID AND GROUP II INTRON REVERSE TRANSCRIPTASESR01GM037949 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LAMBOWITZ, ALAN M. · 1986 to 2019
$8.6MHoward Hughes Medical InstituteNIGMS NIH HHS R01 GM037706NIGMS NIH HHS R01 GM037949NIGMS NIH HHS T32 GM007790
Abstract
Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the
Indexed as
Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsCRISPR-Associated ProteinsGenes, BacterialGene Transfer, HorizontalPhylogenyRNARNA-Directed DNA PolymeraseSpirulinaCRISPR-Associated ProteinsRNARNA-Directed DNA PolymeraseCRISPRcyanobacteriadeep sequencinghorizontal gene transferhost-parasite relationshipphylogenyreverse transcriptaseRNA spacer acquisition
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.