Evidence map›Paper›PMID 28698274›Full record

ArticlemBio2017

Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine-Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2.

Broc T McCune, Wei Tang, Jia Lu, James B Eaglesham, Lucy Thorne, Anne E Mayer, Emily Condiff, Timothy J Nice, Ian Goodfellow, Andrzej M Krezel and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 63 citations in OpenAlex.

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  8. Single-cell profiling of African swine fever virus disease in the pig spleen reveals viral and host dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  15. Ebola Virus Encodes Two microRNAs in Huh7-Infected Cells.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Broc T McCuneDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Wei TangDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
Jia LuDepartment of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom.
James B EagleshamDepartment of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom.
Lucy ThorneDepartment of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom.
Anne E MayerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Emily CondiffDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Timothy J NiceDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ian GoodfellowDepartment of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom.
Andrzej M KrezelDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA virgin@wustl.edu.
Washington University in St. Louis · USUniversity of Cambridge · GB

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Genetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 2014 to 2018
$32.7M
Viral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI BYUN, MINJI · 2001 to 2015
$8.9M
DEFINING THE IN VIVO ROLE OF DAP1 IN AUTOPHAGY AND COLITISF31CA177194 · NCI · WASHINGTON UNIVERSITY · PI MCCUNE, BROC TAYLOR · 2013 to 2015
$87k
GENE TRANSFER INTO HUMAN HEMATOPOIETIC CELLSK08CA001176 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HOCK, RANDY A · 1986 to 1990
–
Biotechnology and Biological Sciences Research Council BB/N001176/1NCI NIH HHS F31 CA177194NCI NIH HHS P30 CA091842NIAID NIH HHS U19 AI109725NIAMS NIH HHS P30 AR048335Wellcome TrustWellcome Trust 097997/Z/11/Z
6 · The paper itself

Abstract

The

Indexed as

Host-Pathogen InteractionsVirus ReplicationAmino Acid MotifsAnimalsCell LineHEK293 CellsHumansMiceNorovirusPhenylalanineRAW 264.7 CellsReverse GeneticsRNA, ViralVesicular Transport ProteinsViral Nonstructural ProteinsPhenylalanineRNA, ViralVAPA protein, humanVAPB protein, humanVesicular Transport ProteinsViral Nonstructural Proteinsnorovirusesplus-strand RNA virusprotein structure-functionreverse genetic analysisviral replicationvirus-host interactions

Identifiers

PMID28698274
PMCPMC5513711
OpenAlexW2735492417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.