Observational studyJournal of the American Heart Association2017
Reversibility of Cardiac Function Predicts Outcome After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
Observational study in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05069168 (Predictors of Left Ventricular Systolic Function Recovery After Transcatheter Aortic Valve), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictors of Left Ventricular Systolic Function Recovery After Transcatheter Aortic Valve
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of ventricular longitudinal strain in patients undergoing transcatheter aortic valve replacement: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Cardiac structural changes after transcatheter aortic valve replacement: systematic review and meta-analysis of cardiovascular magnetic resonance studies.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Pooled it
- Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Trial
- Paravalvular regurgitation after transcatheter aortic valve replacement in intermediate-risk patients: a pooled PARTNER 2 study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Trial
- Reverse remodeling after aortic valve intervention in patients with aortic stenosis: echocardiographic assessments and prognostic implications.Journal of echocardiography · 2026Review
- Article
- Strain characterization of multi-chamber cardiac dysfunction and associated prognosis in patients undergoing TAVR for severe AS.Echo research and practice · 2026Article
- Time-robust myocardial [European journal of nuclear medicine and molecular imaging · 2026Article
- A risk assessment nomogram for cardiac remodeling in the multimorbid geriatric patients: a retrospective study.BMC geriatrics · 2026Article
- Preprocedural computed tomography angiography aortic root geometry and 1-year left ventricular reverse remodeling after transcatheter aortic valve replacement.Frontiers in cardiovascular medicine · 2026Article
- Transcatheter aortic valve implantation improves left ventricular function and hemodynamics and reduces severe ventricular arrhythmias in patients with severe aortic stenosis.BMC cardiovascular disorders · 2025Article
- Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement.GeroScience · 2025Article
- Homeometric autoregulation in severe aortic stenosis: insights from transcatheter aortic valve replacement.Frontiers in cardiovascular medicine · 2025Article
- Impact of Transcatheter Aortic Valve Implantation (TAVI) on Left Ventricular Mass, Volumes, and Pressure. A Single-center Echocardiographic Analysis.Journal of the Saudi Heart Association · 2025Article
- Long-term prognostic value of the HESC heart failure · 2024Article
- Changes in Global Longitudinal Strain after TAVI: Additional Prognostic Value over Cardiac Damage in Patients with Severe Aortic Stenosis.Journal of clinical medicine · 2024Article
- Impact of Transcatheter Aortic Valve Replacement on Cardiac Reverse Remodeling and Prognosis in Mixed Aortic Valve Disease.Journal of the American Heart Association · 2024Article
- Impact of mitral regurgitation aetiology on the outcomes of transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- Cardiac Reversibility and Survival After Transcatheter Aortic Valve Implantation in Patients With Low-Gradient Aortic Stenosis.Journal of the American Heart Association · 2023Article
- Aortic Stenosis Phenotypes and Precision Transcatheter Aortic Valve Implantation.Journal of cardiovascular development and disease · 2023Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReversibility of left ventricular (LV) dysfunction in high-risk aortic stenosis patient and its impact on survival after transcatheter aortic valve replacement (TAVR) are unclear. We aimed to evaluate longitudinal changes of LV structure and function after TAVR and their impact on survival. METHODS AND
resultsWe studied 209 patients with aortic stenosis who underwent TAVR from May 2006 to December 2012. Echocardiograms were used to calculate LV end-diastolic volume index (LVEDVi), LV ejection fraction, LV mass index (LVMi), and global longitudinal strain before, immediately (<10 days), late (1-3 months), and yearly after TAVR. During a median follow-up of 1345 days, 118 patients died, with 26 dying within 1 year. Global longitudinal strain, LVEDVi, LV ejection fraction, and LVMi improved during follow-up. In patients who died during the first year, death was preceded by LVEDVi and LVMi increase. Multivariable longitudinal data analysis showed that aortic regurgitation at baseline, aortic regurgitation at 30 days, and initial LVEDVi were independent predictors of subsequent LVEDVi. In a joint analysis of longitudinal and survival data, baseline Society of Thoracic Surgeons score was predictive of survival, with no additive effect of longitudinal changes in LVEDVi, LVMi, global longitudinal strain, or LV ejection fraction. Presence of aortic regurgitation at 1 month after TAVR was the only predictor of 1-year survival.
conclusionsLV reverse remodeling was observed after TAVR, whereas lack of LVEDVi and LVMi improvement was observed in patients who died during the first year after TAVR. Post-TAVR, aortic regurgitation blocks reverse remodeling and is associated with poor 1-year survival after TAVR.
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