Evidence map›Paper›PMID 28698222›Full record

SynthesisBritish journal of sports medicine2018

A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults.

Robert W Morton, Kevin T Murphy, Sean R McKellar, Brad J Schoenfeld, Menno Henselmans, Eric Helms, Alan A Aragon, Michaela C Devries, Laura Banfield, James W Krieger and 1 more

Erratum issued 2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 544 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
544citing papers in PubMed, 25 pooled it
41.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04734951 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of a Power/Resistance Exercise Program and Oral Supplementation With Beta-hydroxy-beta-methyl Butyrate (HMB) on the Muscle Quality Index in Older Adults. A Randomized Controlled Trial

TypeinterventionalSponsorInstituto Nacional de RehabilitacionRan2023 to 2024Enrolled76ConditionsAging WellArmsPower/resistance exercise program, HMB supplementation
NCT06885736 narecruitingnot on this mapstarted 2025, after this paper: background citation

LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide and Tirzepatide Therapy (LEAN-PREP Study)

TypeinterventionalSponsorDasman Diabetes InstituteRan2025 to 2029Enrolled232ConditionsObesityArmsResistance exercise, Protein Intake
3 · Its place in the literature

Who cites it

544 citing papers in PubMed, 25 syntheses or guidelines pooled it, 1,023 citations in OpenAlex.

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484 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Robert W MortonDepartment of Kinesiology, McMaster University, Hamilton, Canada.
Kevin T MurphyDepartment of Kinesiology, McMaster University, Hamilton, Canada.
Sean R McKellarDepartment of Kinesiology, McMaster University, Hamilton, Canada.
Brad J SchoenfeldDepartment of Health Sciences, Lehman College of CUNY, Bronx, New York, USA.
Menno HenselmansBayesian Bodybuilding, Gorinchem, Netherlands.
Eric HelmsSport Performance Research Institute New Zealand, AUT University, Auckland, New Zealand.
Alan A AragonCalifornia State University, Northridge, California, USA.
Michaela C DevriesDepartment of Kinesiology, University of Waterloo, Waterloo, Canada.
Laura BanfieldHealth Sciences Library, McMaster University, Hamilton, Canada.
James W KriegerWeightology, LLC, Issaquah, Washington, USA.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, Canada.ORCID http://orcid.org/0000-0002-1956-4098
McMaster University · CAAuckland University of Technology · NZCalifornia State University, Northridge · USLehman College · USUniversity of Waterloo · CAWashington Center for Weight Management and Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe performed a systematic review, meta-analysis and meta-regression to determine if dietary protein supplementation augments resistance exercise training (RET)-induced gains in muscle mass and strength. DATA SOURCES: A systematic search of Medline, Embase, CINAHL and SportDiscus. ELIGIBILITY CRITERIA: Only randomised controlled trials with RET ≥6 weeks in duration and dietary protein supplementation.

designRandom-effects meta-analyses and meta-regressions with four a priori determined covariates. Two-phase break point analysis was used to determine the relationship between total protein intake and changes in fat-free mass (FFM).

resultsData from 49 studies with 1863 participants showed that dietary protein supplementation significantly (all p<0.05) increased changes (means (95% CI)) in: strength-one-repetition-maximum (2.49 kg (0.64, 4.33)), FFM (0.30 kg (0.09, 0.52)) and muscle size-muscle fibre cross-sectional area (CSA; 310 µm SUMMARY/

conclusionDietary protein supplementation significantly enhanced changes in muscle strength and size during prolonged RET in healthy adults. Increasing age reduces and training experience increases the efficacy of protein supplementation during RET. With protein supplementation, protein intakes at amounts greater than ~1.6 g/kg/day do not further contribute RET-induced gains in FFM.

Indexed as

Dietary SupplementsMuscle StrengthResistance TrainingAdultDietary ProteinsHumansMuscle, SkeletalRandomized Controlled Trials as TopicRegression AnalysisDietary Proteinsgrowthhypertrophyperformance. leucinesupplementwhey

Identifiers

PMID28698222
PMCPMC5867436
OpenAlexW2735395116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.