Evidence map›Paper›PMID 28697775›Full record

ArticleBMC oral health2017

The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children.

Yuan-Yuan Kong, Jian-Mao Zheng, Wen-Juan Zhang, Qian-Zhou Jiang, Xue-Chao Yang, Miao Yu, Su-Juan Zeng

Open access · goldAbstract read
In one paragraph

Article in BMC oral health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. [Polymorphisms associated with dental caries in pediatric populations: a systematic review].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Pooled it
  4. Association Between theGenetic testing and molecular biomarkers · 2021
    Pooled it
  5. Article
  6. Article
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  8. The association betweenHealth science reports · 2023
    Article
  9. Article
  10. The Most Common Vitamin D Receptor Polymorphisms (Children (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms inJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuan-Yuan KongKey Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, 39# Huangsha Road, Guangzhou, 510140, China.
Jian-Mao ZhengGuangdong Provincial Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Sun Yat-sen University, Guangzhou, 510140, China.
Wen-Juan ZhangDepartment of Endodontics, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.
Qian-Zhou JiangKey Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, 39# Huangsha Road, Guangzhou, 510140, China. jqianzhou@126.com.
Xue-Chao YangDepartment of Oral Digital Center, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.
Miao YuDepartment of Dongfengxi Clinic, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.
Su-Juan ZengDepartment of Pediatric Dentistry, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.
Stomatology Hospital · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children.

methodsOur study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP.

resultsThe adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1.856, 95% CI = [1.184, 2.908], p = 0.007). However, VDR polymorphisms ApaI, TaqI and FokI were not associated with deciduous tooth decay (ApaI: OR = 0.839, 95% CI = [0.614, 1.145], p = 0.268; TaqI: OR = 1.150, 95% CI = [0.495, 2.672], p = 0.744; FokI: OR = 0.856, 95% CI = [0.616, 1.191], p = 0.356).

conclusionsOur results showed that VDR BsmI polymorphism was associated with the risk of deciduous tooth decay in Chinese children aged 4-7 years. However, the specific mechanism remains to further verify through experiment.

Indexed as

Tooth, DeciduousChildChild, PreschoolChinaDental CariesFemaleGenetic Association StudiesHumansMalePolymorphism, GeneticReal-Time Polymerase Chain ReactionReceptors, CalcitriolReceptors, CalcitriolDeciduous tooth decayGene polymorphismsVitamin D receptor

Identifiers

PMID28697775
PMCPMC5505030
OpenAlexW2734825392

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.