ArticleBMC cardiovascular disorders2017
Effect of neuroticism on risk of cardiovascular disease in depressed persons - a Swedish population-based cohort study.
Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Association between specific neuroticism symptoms and cardiovascular disease: insights from genetic analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between neuroticism, genetic susceptibility, and peripheral artery disease risk: a prospective study in UK Biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Examining the Role of Neuroticism Polygenic Risk in Late Life Cognitive Change: A UK Biobank Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- Can flow proneness be protective against mental and cardiovascular health problems? A genetically informed prospective cohort study.Translational psychiatry · 2024Article
- Article
- Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study.Frontiers in genetics · 2022Article
- Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses.Frontiers in oncology · 2022Article
- Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.General psychiatry · 2022Article
- Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults.Scientific reports · 2021Article
- Is stressor-evoked cardiovascular reactivity a pathway linking positive and negative emotionality to preclinical cardiovascular disease risk?Psychophysiology · 2021Article
- Depressive symptomatology and personality traits in patients with symptomatic and asymptomatic peripheral arterial disease.BMC cardiovascular disorders · 2020Article
- Anxiety and Extraversion in Lupus-Related Atherosclerosis.Frontiers in psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between neuroticism, depression and cardiovascular disease (CVD) is complex and has so far not been studied in depth. The aim of this study was to determine if neuroticism is an effect-modifier in the association between depression and CVD. Data derived from a longitudinal cohort study on mental health, work and relations among adults (20-64 years), including 10,443 individuals. Depression was assessed using the Major Depression Inventory (MDI) and neuroticism by the Swedish Scale of Personality (SSP). Outcomes of cardiovascular disease were register-based from the National inpatient register.
resultsBoth depression (OR 1.9 (95%CI 1.4, 2.5)) and high levels of neuroticism (OR 1.2 (95%CI 1.1-1.3)) were associated with increased risk of CVD. The combined effect of depression and neuroticism on the risk of CVD revealed HRs ranging from 1.0 to 1.9 after adjusting for age and gender, socioeconomic position, prevalent hypertension and diabetes. Almost similar associations were seen after further adjustment for lifestyle factors.
conclusionNeuroticism increased the risk of CVD in depressed persons. We found synergistic interaction between neuroticism and depression status in predicting future risk of CVD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.