ArticleJournal of the American Chemical Society2017
Retuning the Catalytic Bias and Overpotential of a [NiFe]-Hydrogenase via a Single Amino Acid Exchange at the Electron Entry/Exit Site.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Biomedical utility of zinc and copper mediated cerium oxide nanoparticles.RSC advances · 2026Article
- Lessons, connections, hypotheses and predictions from protein film electrochemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Review
- Decoding the Elusive Redox Properties of [FeS] Clusters in [FeFe]-Hydrogenase on a Nanostructured Electrode.Journal of the American Chemical Society · 2025Article
- Cyanophenylalanine as an Infrared Probe for Iron-Sulfur Cluster Redox State in Multicenter Metalloenzymes.Chembiochem : a European journal of chemical biology · 2025Article
- A semisynthetic, multicofactor artificial metalloenzyme retains independent site activity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Article
- Practical Guide to Large Amplitude Fourier-Transformed Alternating Current Voltammetry-What, How, and Why.ACS measurement science au · 2024Article
- Applying Nuclear Forward Scattering asJournal of the American Chemical Society · 2024Article
- Outer-sphere effects on the OChemical science · 2024Review
- Advanced Electroanalysis for Electrosynthesis.ACS organic & inorganic Au · 2024Review
- Article
- Transport limited adsorption experiments give a new lower estimate of the turnover frequency ofBBA advances · 2023Article
- Enzymatic and Microbial Electrochemistry: Approaches and Methods.ACS measurement science au · 2022Review
- Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase.Chemical reviews · 2022Review
- A site-differentiated [4Fe-4S] cluster controls electron transfer reactivity ofChemical science · 2022Article
- The crystalline state as a dynamic system: IR microspectroscopy under electrochemical control for a [NiFe] hydrogenase.Chemical science · 2021Article
- Reversible catalysis.Nature reviews. Chemistry · 2021Review
- Selective cysteine-to-selenocysteine changes in a [NiFe]-hydrogenase confirm a special position for catalysis and oxygen tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Catalytic bias in oxidation-reduction catalysis.Chemical communications (Cambridge, England) · 2021Article
- Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.Microbiology and molecular biology reviews : MMBR · 2020Review
- Tuning Catalytic Bias of Hydrogen Gas Producing Hydrogenases.Journal of the American Chemical Society · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The redox chemistry of the electron entry/exit site in Escherichia coli hydrogenase-1 is shown to play a vital role in tuning biocatalysis. Inspired by nature, we generate a HyaA-R193L variant to disrupt a proposed Arg-His cation-π interaction in the secondary coordination sphere of the outermost, "distal", iron-sulfur cluster. This rewires the enzyme, enhancing the relative rate of H
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Registered trials
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