Evidence map›Paper›PMID 28697326›Full record

ArticleThe American journal of pathology2017

Laminin-Dependent Interaction between Astrocytes and Microglia: A Role in Retinal Angiogenesis.

Saptarshi Biswas, Galina Bachay, Julianne Chu, Dale D Hunter, William J Brunken

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Laminins and the blood-brain barrier.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Frontiers in diabetic retinal disease.Journal of diabetes and its complications · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Key Role of Astrocytes in Postnatal Brain and Retinal Angiogenesis.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Review
  16. Cytokine Signalling at the Microglial Penta-Partite Synapse.International journal of molecular sciences · 2021
    Review
  17. Cerebrovascular development: mechanisms and experimental approaches.Cellular and molecular life sciences : CMLS · 2021
    Review
  18. Laminin β2 Chain Regulates Cell Cycle Dynamics in the Developing Retina.Frontiers in cell and developmental biology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Saptarshi BiswasDepartment of Ophthalmology, State University of New York Upstate Medical University, Syracuse, New York; Department of Ophthalmology, State University of New York Downstate Medical Center, Brooklyn, New York; Center for Vision Research, Syracuse, New York.
Galina BachayDepartment of Ophthalmology, State University of New York Upstate Medical University, Syracuse, New York; Department of Ophthalmology, State University of New York Downstate Medical Center, Brooklyn, New York; Center for Vision Research, Syracuse, New York.
Julianne ChuDepartment of Ophthalmology, State University of New York Downstate Medical Center, Brooklyn, New York.
Dale D HunterDepartment of Ophthalmology, State University of New York Upstate Medical University, Syracuse, New York; Department of Ophthalmology, State University of New York Downstate Medical Center, Brooklyn, New York; Center for Vision Research, Syracuse, New York.
William J BrunkenDepartment of Ophthalmology, State University of New York Upstate Medical University, Syracuse, New York; Department of Ophthalmology, State University of New York Downstate Medical Center, Brooklyn, New York; Center for Vision Research, Syracuse, New York. Electronic address: brunkenw@upstate.edu.
State University of New York · US

Funding

Role of Extracellular Matrix in Retinal Development and DiseaseR01EY012676 · NEI · UPSTATE MEDICAL UNIVERSITY · PI BRUNKEN, WILLIAM J · 2000 to 2021
$6.9M
NEI NIH HHS R01 EY012676
6 · The paper itself

Abstract

Retinal vascular diseases are among the leading causes of acquired blindness. In recent years, retinal microglia have been shown to influence vascular branching density and endothelial cell proliferation. However, how microglial recruitment and activation are regulated during development remains unclear. We hypothesized that microglial recruitment, activation, and down-stream signaling are modulated by components of the mural basement membrane. We used a reverse genetic approach to disrupt laminin expression in the vascular basement membrane and demonstrate that microglia respond to the mural basement membrane in an isoform-specific manner. Microglial density is significantly increased in the laminin γ3-null (Lamc3

Indexed as

AnimalsAstrocytesBasement MembraneEndothelial CellsLamininMiceMicrogliaRetinaRetinal NeovascularizationTransforming Growth Factor beta1Lamc3 protein, mouseLamininTransforming Growth Factor beta1

Identifiers

PMID28697326
PMCPMC5808181
OpenAlexW2729085802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.