ArticleJournal of biomedical optics2017
Handheld optical coherence tomography-reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Noninvasive Multimodal Imaging and Its Role in Diagnosing Skin Lesions in Dermatology: A Systematic Review and Meta-Analysis.American journal of clinical dermatology · 2025Pooled it
- Review
- Comparison of Noninvasive Methods for Diagnosing Basal Cell Carcinoma: A Network Meta-Analysis.Indian dermatology online journal · 2026Article
- Advanced Microscopy Techniques.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- One-Stop Shop: Diagnosis and Treatment of Basal Cell Carcinoma in One Step.Journal of clinical medicine · 2024Review
- Wearable optical coherence tomography angiography probe for freely moving mice.Biomedical optics express · 2023Article
- Self-supervised denoising of Nyquist-sampled volumetric images via deep learning.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Confocal Microscopy for Diagnosis and Management of Cutaneous Malignancies: Clinical Impacts and Innovation.Diagnostics (Basel, Switzerland) · 2023Review
- Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts.International journal of molecular sciences · 2023Review
- Challenges for New Adopters in Pre-Surgical Margin Assessment by Handheld Reflectance Confocal Microscope of Basal Cell Carcinoma; A Prospective Single-center Study.Dermatology practical & conceptual · 2022Review
- Automatic Segmentation of Laser-Induced Injury OCT Images Based on a Deep Neural Network Model.International journal of molecular sciences · 2022Article
- Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance.Translational biophotonics · 2022Article
- Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma.Journal of the American Academy of Dermatology · 2022Article
- In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment.Journal of biomedical optics · 2022Article
- In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology.Scientific reports · 2021Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- Emerging Minimally Invasive Technologies for the Detection of Skin Cancer.Journal of personalized medicine · 2021Review
- Manually scanned single fiber optical coherence tomography for skin cancer characterization.Scientific reports · 2021Article
- Management of complex head-and-neck basal cell carcinomas using a combined reflectance confocal microscopy/optical coherence tomography: a descriptive study.Archives of dermatological research · 2021Observational
- Angulated small nests and cords: Key diagnostic histopathologic features of infiltrative basal cell carcinoma can be identified using integrated reflectance confocal microscopy-optical coherence tomography.Journal of cutaneous pathology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin <italic<in vivo</italic<. A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a common path hand-held probe. Cross-sectional OCT images and enface RCM images are simultaneously displayed, allowing for three-dimensional microscopic assessment of tumor morphology in real time. Depending on the subtype and depth of the BCC tumor and surrounding skin conditions, OCT and RCM imaging are able to complement each other, the strengths of each helping overcome the limitations of the other. Four representative cases are summarized, out of the 15 investigated in a preliminary pilot study, demonstrating how OCT and RCM imaging may be synergistically combined to more accurately detect BCCs and more completely delineate margins. Our preliminary results highlight the potential benefits of combining the two technologies within a single probe to potentially guide diagnosis as well as treatment of BCCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.