ArticleObstetrics and gynecology2017
Risk of Subsequent Ovarian Cancer After Ovarian Conservation in Young Women With Stage I Endometrioid Endometrial Cancer.
Article in Obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Updates and evolving care paradigms for pre-menopausal patients with endometrial cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026Review
- Molecular and pathologic data to guide selection of patients with endometrioid endometrial cancer for ovarian preservation.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024Article
- Mining of immunological and prognostic-related biomarker for cervical cancer based on immune cell signatures.Frontiers in immunology · 2022Article
- Time Intervals between Double Primary Breast and Ovarian Cancers and Survival Outcomes of Patients with Both Cancers: A SEER Database Analysis.BioMed research international · 2022Article
- Article
- Temporal trends of subsequent breast cancer among women with ovarian cancer: a population-based study.Archives of gynecology and obstetrics · 2020Article
- Evolving population-based statistics for rare epithelial ovarian cancers.Gynecologic oncology · 2020Observational
- Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer.Gynecologic oncology · 2019Article
- Patterns of utilization and outcome of ovarian conservation for young women with minimal-risk endometrial cancer.Gynecologic oncology · 2019Article
- Decreasing secondary primary uterine cancer after breast cancer: A population-based analysis.Gynecologic oncology · 2019Article
- Decreasing Trends of Secondary Primary Colorectal Cancer among Women with Uterine Cancer: A Population-Based Analysis.Journal of clinical medicine · 2019Article
- Association between body mass index and surgical menopausal symptoms in patients with early stage endometrial cancer.Gynecologic oncology · 2019Article
- Tumor-specific outcome of metachronous uterine malignancy after pelvic irradiation for cervical cancer.Gynecologic oncology · 2018Article
- Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis.Gynecologic oncology · 2018Article
- Adequate pelvic lymphadenectomy and survival of women with early-stage epithelial ovarian cancer.Journal of gynecologic oncology · 2018Observational
- Article
- Trends of low-grade serous ovarian carcinoma in the United States.Journal of gynecologic oncology · 2018Article
- Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer.Gynecologic oncology · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the cumulative incidence of subsequent ovarian cancer among young women with stage I endometrioid endometrial cancer who had ovarian conservation at surgical treatment.
methodsThis retrospective study examined the Surveillance, Epidemiology, and End Results Program to identify women aged younger than 50 years who underwent hysterectomy with ovarian conservation for stage I endometrioid endometrial cancer between 1983 and 2013. Time-dependent risk of ovarian cancer diagnosed during the follow-up after endometrial cancer diagnosis was examined.
resultsAmong 1,322 women in the study cohort, 16 women developed subsequent ovarian cancer with 5- and 10-year cumulative incidences of 1.0% and 1.3%, respectively. Median time to develop subsequent ovarian cancer was 2.4 years, and the majority of subsequent ovarian cancer was diagnosed within the first 3 years from the diagnosis of endometrial cancer (68.8%). The majority of subsequent ovarian cancer was endometrioid type (81.3%) and stage I disease (75.0%). With a median follow-up time of 11.6 years, there were no ovarian cancer deaths. Younger age at endometrial cancer diagnosis was significantly associated with increased risk of subsequent ovarian cancer (10-year cumulative incidences: age younger than 40 compared with 40-49 years, 2.6% compared with 0.4%, hazard ratio 5.00, 95% confidence interval [CI] 1.60-15.7, P=.002).
conclusionYoung women with stage I endometrioid endometrial cancer have an approximately 1% risk of developing subsequent ovarian cancer after ovarian conservation at the time of hysterectomy that was associated with favorable tumor factors resulting in good ovarian cancer-specific survival. Our results endorse the importance of genetic testing and close follow-up when counseling about this procedure, especially for those who are younger than 40 years.
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