Trial reportAnnals of surgery2017
Transfusion Requirement in Burn Care Evaluation (TRIBE): A Multicenter Randomized Prospective Trial of Blood Transfusion in Major Burn Injury.
Trial report in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01079247 (A Randomized Clinical Trial of Restrictive vs. Traditional Blood Transfusion Practices in Burn Patients), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Clinical Trial of Restrictive vs. Traditional Blood Transfusion Practices in Burn Patients
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Patient-centred outcomes are under-reported in the critical care burns literature: a systematic review.Trials · 2022Pooled it
- Transfusion thresholds for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2021Pooled it
- Liberal versus restrictive red blood cell transfusion strategy in sepsis or septic shock: a systematic review and meta-analysis of randomized trials.Critical care (London, England) · 2019Pooled it
- A Clinical Investigation of Hypoxic Red Blood Cell Administration in Patients with Transfusion-Dependent Hematological Malignancies and Burns.Journal of blood medicine · 2026Trial
- Examining 1:1 vs. 4:1 Packed Red Blood Cell to Fresh Frozen Plasma Ratio Transfusion During Pediatric Burn Excision.Journal of burn care & research : official publication of the American Burn Association · 2020Trial
- Restrictive Transfusion Strategy Is More Effective in Massive Burns: Results of the TRIBE Multicenter Prospective Randomized Trial.Military medicine · 2019Trial
- The Effects of Storage Age of Blood in Massively Transfused Burn Patients: A Secondary Analysis of the Randomized Transfusion Requirement in Burn Care Evaluation Study.Critical care medicine · 2018Trial
- [Interpretation of the 2025Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Blood product transfusion in major burned pediatric patients: A case-control study.Turkish journal of surgery · 2026Article
- Current perspectives and updates on transfusion strategies in critically ill anemic patients.Frontiers in medicine · 2026Review
- Transfusion requirements as a surrogate marker of mortality and morbidity in adults with severe burns: A retrospective cohort study.Turkish journal of surgery · 2025Article
- Evaluation of Tranexamic Acid for the Reduction of Blood Loss During Burn Surgery in Adults (Tranburn Study).Annals of burns and fire disasters · 2025Article
- [Interpretation of the 2023 International Society for Burn Injuries "Surviving Sepsis After Burn Campaign"].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- The effect of allogeneic blood transfusion on burn mortality in a resource-limited setting.Burns : journal of the International Society for Burn Injuries · 2025Article
- Mortality in Critically Ill Patients with Liberal Versus Restrictive Transfusion Thresholds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.Journal of clinical medicine · 2025Review
- Impact of red blood cell transfusion in massive burn: a multicenter cohort study.Scientific reports · 2025Article
- The risk factors of plasma transfusions during resuscitation in pediatric burn patients: a retrospective study from 2010 to 2021.Frontiers in pediatrics · 2025Article
- The Red-cell Transfusion Strategy Dilemma in Critically Ill Patients in ICU: Is Restrictive or Liberal the Answer?Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025Review
- Total Body Surface Area Adjusted Daily Diagnostic Blood Loss May Be Higher in Minor Burns-Are Our Patients the Victims of Daily Routine?European burn journal · 2024Article
- Predictors for anaemia, blood transfusion and outcome in plastic surgery patients.The Journal of international medical research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 12 institutions in 3 countries.
Funding
Abstract
objectiveOur objective was to compare outcomes of a restrictive to a liberal red cell transfusion strategy in 20% or more total body surface area (TBSA) burn patients. We hypothesized that the restrictive group would have less blood stream infection (BSI), organ dysfunction, and mortality.
backgroundPatients with major burns have major (>1 blood volume) transfusion requirements. Studies suggest that a restrictive blood transfusion strategy is equivalent to a liberal strategy. However, major burn injury is precluded from these studies. The optimal transfusion strategy in major burn injury is thus needed but remains unknown.
methodsThis prospective randomized multicenter trial block randomized patients to a restrictive (hemoglobin 7-8 g/dL) or liberal (hemoglobin 10-11 g/dL) transfusion strategy throughout hospitalization. Data collected included demographics, infections, transfusions, and outcomes.
resultsEighteen burn centers enrolled 345 patients with 20% or more TBSA burn similar in age, TBSA burn, and inhalation injury. A total of 7054 units blood were transfused. The restrictive group received fewer blood transfusions: mean 20.3 ± 32.7 units, median = 8 (interquartile range: 3, 24) versus mean 31.8 ± 44.3 units, median = 16 (interquartile range: 7, 40) in the liberal group (P < 0.0001, Wilcoxon rank sum). BSI incidence, organ dysfunction, ventilator days, and time to wound healing (P > 0.05) were similar. In addition, there was no 30-day mortality difference: 9.5% restrictive versus 8.5% liberal (P = 0.892, χ test).
conclusionsA restrictive transfusion strategy halved blood product utilization. Although the restrictive strategy did not decrease BSI, mortality, or organ dysfunction in major burn injury, these outcomes were no worse than the liberal strategy (Clinicaltrials.gov identifier NCT01079247).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.