ArticleSmall GTPases2020
Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Article in Small GTPases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Rab12 is a regulator of mitophagy and mitochondrial homeostasis.bioRxiv : the preprint server for biology · 2026Article
- A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes.Journal of translational medicine · 2024Article
- Article
- Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation.Cell discovery · 2023Article
- Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.Nature communications · 2023Article
- Cardiovascular aging: the mitochondrial influence.The journal of cardiovascular aging · 2023Article
- The Role of Rab Proteins in Mitophagy: Insights into Neurodegenerative Diseases.International journal of molecular sciences · 2023Review
- A membrane reticulum, the centriculum, affects centrosome size and function in Caenorhabditis elegans.Current biology : CB · 2023Article
- Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy.Science signaling · 2023Article
- Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation.Nature communications · 2023Article
- V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.The Journal of cell biology · 2023Article
- Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.Autophagy · 2022Article
- Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner.Science advances · 2022Article
- Review
- Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles.The EMBO journal · 2020Article
- Exosomes from Human Periapical Cyst-MSCs: Theranostic Application in Parkinson's Disease.International journal of medical sciences · 2020Review
- Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin.Frontiers in physiology · 2020Review
- ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.Nature communications · 2019Article
- Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.Life science alliance · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Degradation of mitochondria is an important cellular quality control mechanism mediated by two distinct pathways: one involving Parkin-mediated ubiquitination and the other dependent on mitophagy receptors. It is known that mitochondria are degraded by the autophagy pathway; however, we recently reported that the small GTPase Rab5 and early endosomes also participate in Parkin-mediated mitochondrial clearance. Here, we have developed a protocol to isolate Rab5-positive vesicles from cells for proteomics analysis and provide additional data confirming that mitophagy regulators and mitochondrial proteins are present in these vesicles. We also demonstrate that the mitophagy receptor BNIP3 utilizes the Rab5-endosomal pathway to clear mitochondria in cells. These findings indicate that a redundancy exists in the downstream degradation pathways to ensure efficient mitochondrial clearance.
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Registered trials
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