ReviewJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2017
Heterogeneity and Stability in Foxp3+ Regulatory T Cells.
Review in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Cytokine-independent activation of STAT5 promotes the persistence and function of CD4Molecular therapy. Advances · 2026Article
- Impaired Treg-Mediated Immune Regulation in Peri-Implantitis Lesions and Implant Loss: Insights From Histological and Molecular Analyses.Journal of clinical periodontology · 2025Article
- Article
- Preclinical development of a novel CCR8/CTLA-4 bispecific antibody for cancer treatment by disrupting CTLA-4 signaling on CD8 T cells and specifically depleting tumor-resident Tregs.Cancer immunology, immunotherapy : CII · 2024Article
- Review
- Bone Morphogenetic Proteins Shape TFrontiers in immunology · 2022Review
- Highly Purified Alloantigen-Specific Tregs From Healthy and Chronic Kidney Disease Patients Can Be Long-Term Expanded, Maintaining a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines.Frontiers in immunology · 2021Article
- Coexpression of Helios in Foxp3Disease markers · 2021Review
- Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease.Frontiers in immunology · 2020Article
- Stability and inhibitory function of Treg cells under inflammatory conditionsExperimental and therapeutic medicine · 2019Article
- Salivary gland immunizationFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Article
- Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells.Journal of immunology research · 2018Review
- A Comparison of Automated Perfusion- and Manual Diffusion-Based Human Regulatory T Cell Expansion and Functionality Using a Soluble Activator Complex.Cell transplantationArticle
- Functional Impairment of Activated Regulatory T Cells as a Central Immunological Defect in Endometriosis.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foxp3+ regulatory T cells (Tregs) play an indispensable role in controlling tolerance and immunity against self- and foreign antigens. The failure of Tregs to properly function is the direct cause of systemic and chronic inflammation as well as immune suppression. It is now evident that Tregs are highly heterogeneous populations depending on the surface phenotypes, cytokine profiles, and anatomical locations. Yet, our understanding of the cellular and molecular pathways underlying such heterogeneity is very limited. Furthermore, some Tregs lose the phenotype (and suppressive functions) and instead acquire pathogenicity. Since utilizing Tregs as a tool for immunotherapy is being implemented in many clinical settings, it is of utmost importance to understand the precise mechanisms by which the loss of Treg phenotype (and function) is prevented. In this review, both cellular and molecular factors involved in Treg heterogeneity and stability are discussed.
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Registered trials
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