ArticleSmall (Weinheim an der Bergstrasse, Germany)2017
Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating.
Article in Small (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- The Nature of Non-Arrhenius Kinetics in the Heat Denaturation of Proteins.International journal of molecular sciences · 2026Article
- Regulating nanoscale directional heat transfer with Janus nanoparticles.Nanoscale advances · 2024Article
- Enhanced Nanobubble Formation: Gold Nanoparticle Conjugation to Qβ Virus-like Particles.ACS nano · 2023Article
- Curvature and temperature-dependent thermal interface conductance between nanoscale gold and water.The Journal of chemical physics · 2022Article
- Single pulse heating of a nanoparticle array for biological applications.Nanoscale advances · 2022Article
- Current Strategies for Real-Time Enzyme Activation.Biomolecules · 2022Review
- Spatiotemporal Evolution of Temperature During Transient Heating of Nanoparticle Arrays.Journal of heat transfer · 2022Article
- Modelling of the dynamic polarizability of macromolecules for single-molecule optical biosensing.Scientific reports · 2022Article
- Computational Investigation of Protein Photoinactivation by Molecular Hyperthermia.Journal of biomechanical engineering · 2021Article
- Aggregation affects optical properties and photothermal heating of gold nanospheres.Scientific reports · 2021Article
- Near-Infrared Light Triggered-Release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles.Angewandte Chemie (International ed. in English) · 2020Article
- Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia.ACS nano · 2019Article
- Theoretical and experimental modeling of interstitial laser hyperthermia with surface cooling device using NdLasers in medical science · 2019Article
- Non-Arrhenius Reaction-Diffusion Kinetics for Protein Inactivation over a Large Temperature Range.ACS nano · 2019Article
- Stimulus-Responsive Regulation of Enzyme Activity for One-Step and Multi-Step Syntheses.Advanced synthesis & catalysis · 2019Review
- Microscale direct measurement of localized photothermal heating in tissue-mimetic hydrogels.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Spatiotemporal control of protein structure and activity in biological systems has important and broad implications in biomedical sciences as evidenced by recent advances in optogenetic approaches. Here, this study demonstrates that nanosecond pulsed laser heating of gold nanoparticles (GNP) leads to an ultrahigh and ultrashort temperature increase, coined as "molecular hyperthermia", which causes selective unfolding and inactivation of proteins adjacent to the GNP. Protein inactivation is highly dependent on both laser pulse energy and GNP size, and has a well-defined impact zone in the nanometer scale. It is anticipated that the fine control over protein structure and function enabled by this discovery will be highly enabling within a number of arenas, from probing the biophysics of protein folding/unfolding to the nanoscopic manipulation of biological systems via an optical trigger, to developing novel therapeutics for disease treatment without genetic modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.