Evidence map›Paper›PMID 28696433›Full record

ArticleMolecular psychiatry2018

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.

K Goozee, P Chatterjee, I James, K Shen, H R Sohrabi, P R Asih, P Dave, C ManYan, K Taddei, S J Ayton and 6 more

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PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 64 citations in OpenAlex.

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  14. Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging.International journal of molecular and cellular medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

K Goozee *Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
P Chatterjee *Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
I JamesInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia.
K ShenAustralian eHealth Research Centre, CSIRO, Floreat, WA, Australia.
H R SohrabiDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
P R AsihKaRa Institute of Neurological Disease, Sydney, NSW, Australia.
P DaveDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
C ManYanAnglicare, Sydney, NSW, Australia.
K TaddeiSchool of Medical Health and Sciences, Edith Cowan University, Perth, WA, Australia.
S J AytonFlorey Department of Neuroscience and Mental Health, University of Melbourne University, Melbourne, VIC, Australia.
M L GargNutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
J B KwokSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
A I BushThe Cooperative Research Centre for Mental Health, Carlton, VIC, Australia.
R ChungDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
J S MagnussenDepartment of Clinical Medicine, Macquarie University, Sydney, NSW, Australia.
R N MartinsDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia. r.martins@ecu.edu.au.
Edith Cowan University · AUMacquarie University · AUUniversity of Melbourne · AUAustralian Alzheimer’s Research Foundation · AUCommonwealth Scientific and Industrial Research Organisation · AUCooperative Research Centre for Mental Health · AUKaRaMinds · AUMurdoch University · AUUniversity of Newcastle Australia · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferritin, an iron storage and regulation protein, has been associated with Alzheimer's disease (AD); however, it has not been investigated in preclinical AD, detected by neocortical amyloid-β load (NAL), before cognitive impairment. Cross-sectional analyses were carried out for plasma and serum ferritin in participants in the Kerr Anglican Retirement Village Initiative in Aging Health cohort. Subjects were aged 65-90 years and were categorized into high and low NAL groups via positron emission tomography using a standard uptake value ratio cutoff=1.35. Ferritin was significantly elevated in participants with high NAL compared with those with low NAL, adjusted for covariates age, sex, apolipoprotein E ɛ4 carriage and levels of C-reactive protein (an inflammation marker). Ferritin was also observed to correlate positively with NAL. A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished high from low NAL (area under the curve (AUC)=0.766), but was outperformed when plasma ferritin was added to the base model (AUC=0.810), such that at 75% sensitivity, the specificity increased from 62 to 71% on adding ferritin to the base model, indicating that ferritin is a statistically significant additional predictor of NAL over and above the base model. However, ferritin's contribution alone is relatively minor compared with the base model. The current findings suggest that impaired iron mobilization is an early event in AD pathogenesis. Observations from the present study highlight ferritin's potential to contribute to a blood biomarker panel for preclinical AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E4BiomarkersCohort StudiesC-Reactive ProteinCross-Sectional StudiesFemaleFerritinsHumansMaleNeocortexOrgan SizePositron-Emission TomographyAmyloid beta-PeptidesApolipoprotein E4BiomarkersC-Reactive ProteinFerritins

Identifiers

PMID28696433
OpenAlexW2734340603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.