ArticleThe ISME journal2017
Optimised chronic infection models demonstrate that siderophore 'cheating' in Pseudomonas aeruginosa is context specific.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Biophysical Constraints Dictate the Stability of Social Traits inbioRxiv : the preprint server for biology · 2026Article
- High-risk lineages shape the resistome and virulome of multidrug-resistantFrontiers in cellular and infection microbiology · 2026Article
- Challenging the paradigm: non-canonical exoprotease cheating in clinical Pseudomonas aeruginosa isolates.FEMS microbiology ecology · 2025Article
- Host niche-specific challenges hindering the treatment of polymicrobial infections.Journal of bacteriology · 2025Review
- Exploiting social traits for clinical applications in bacteria and viruses.npj antimicrobials and resistance · 2025Review
- Bacterioplankton taxa compete for iron along the early spring-summer transition in the Arctic Ocean.Ecology and evolution · 2024Article
- Metabolomics of bacterial-fungal pairwise interactions reveal conserved molecular mechanisms.The Analyst · 2023Article
- Metabolomics of bacterial-fungal pairwise interactions reveal conserved molecular mechanisms.bioRxiv : the preprint server for biology · 2023Article
- Copper selects for siderophore-mediated virulence in Pseudomonas aeruginosa.BMC microbiology · 2022Article
- Ecology drives the evolution of diverse social strategies in Pseudomonas aeruginosa.Molecular ecology · 2021Article
- Building a better biofilm - Formation ofBiofilm · 2020Article
- The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection.Infection and immunity · 2020Article
- Siderophore-Mediated Interactions Determine the Disease Suppressiveness of Microbial Consortia.mSystems · 2020Article
- Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogenJournal of medical microbiology · 2020Review
- Pharmacodynamic Functions of Synthetic Derivatives for Treatment of Methicillin-ResistantFrontiers in microbiology · 2020Article
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- The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung.FEMS microbiology letters · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential for siderophore mutants of Pseudomonas aeruginosa to attenuate virulence during infection, and the possibility of exploiting this for clinical ends, have attracted much discussion. This has largely been based on the results of in vitro experiments conducted in iron-limited growth medium, in which siderophore mutants act as social 'cheats:' increasing in frequency at the expense of the wild type to result in low-productivity, low-virulence populations dominated by mutants. We show that insights from in vitro experiments cannot necessarily be transferred to infection contexts. First, most published experiments use an undefined siderophore mutant. Whole-genome sequencing of this strain revealed a range of mutations affecting phenotypes other than siderophore production. Second, iron-limited medium provides a very different environment from that encountered in chronic infections. We conducted cheating assays using defined siderophore deletion mutants, in conditions designed to model infected fluids and tissue in cystic fibrosis lung infection and non-healing wounds. Depending on the environment, siderophore loss led to cheating, simple fitness defects, or no fitness effect at all. Our results show that it is crucial to develop defined in vitro models in order to predict whether siderophores are social, cheatable and suitable for clinical exploitation in specific infection contexts.
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