Evidence map›Paper›PMID 28696394›Full record

ArticleNutrients2017

Influence of Genetic Variations in Selenoprotein Genes on the Pattern of Gene Expression after Supplementation with Brazil Nuts.

Janaina L S Donadio, Marcelo M Rogero, Simon Cockell, John Hesketh, Silvia M F Cozzolino

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03111355 (Genetic Variants in Selenoprotein Genes and Gender Influence Biomarkers of Se Status in Response to Brazil Nut Supplementation in Healthy Brazilians), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03111355 nacompletednot on this map

Genetic Variants in Selenoprotein Genes and Gender Influence Biomarkers of Se Status in Response to Brazil Nut Supplementation in Healthy Brazilians

TypeinterventionalSponsorUniversity of Sao PauloRan2013 to 2016Enrolled129ConditionsDietary SupplementsArmsBrazil nut
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. TheJournal of the Endocrine Society · 2025
    Article
  3. Effects of Regular Brazil Nut (Foods (Basel, Switzerland) · 2022
    Review
  4. A Functional Variant inFrontiers in nutrition · 2021
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Janaina L S DonadioDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil. janainadonadio@gmail.com.
Marcelo M RogeroDepartment of Nutrition, Faculty of Public Health, University of São Paulo, São Paulo 01246-904, Brazil. mmrogero@usp.br.
Simon CockellInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. simon.cockell@newcastle.ac.uk.
John HeskethInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. j.e.hesketh@newcastle.ac.uk.
Silvia M F CozzolinoDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil. janainadonadio@gmail.com.
Universidade de São Paulo · BRNewcastle University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium (Se) is an essential micronutrient for human health. Its beneficial effects are exerted by selenoproteins, which can be quantified in blood and used as molecular biomarkers of Se status. We hypothesize that the presence of genetic polymorphisms in selenoprotein genes may: (1) influence the gene expression of specific selenoproteins and (2) influence the pattern of global gene expression after Brazil nut supplementation. The study was conducted with 130 healthy volunteers in Sao Paulo, Brazil, who consumed one Brazil nut (300 μg/Se) a day for eight weeks. Gene expression of

Indexed as

BertholletiaPolymorphism, Single NucleotideAdultAllelesBiomarkersBody Mass IndexDietGene Expression RegulationGenotyping TechniquesGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansMicroarray AnalysisPhospholipid Hydroperoxide Glutathione PeroxidaseRNA, MessengerSeleniumBiomarkersGlutathione PeroxidaseGlutathione Peroxidase GPX1Phospholipid Hydroperoxide Glutathione PeroxidaseRNA, MessengerSeleniumSelenoprotein PmicroarraymicronutrientpolymorphismsSNPstranscriptomics

Identifiers

PMID28696394
PMCPMC5537853
OpenAlexW2734537792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.