Evidence map›Paper›PMID 28696354›Full record

ArticleInternational journal of molecular sciences2017

A Case of AML Characterized by a Novel t(4;15)(q31;q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy.

Justin M Watts, Aymee Perez, Lutecia Pereira, Yao-Shan Fan, Geoffrey Brown, Francisco Vega, Kevin Petrie, Ronan T Swords, Arthur Zelent

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Targeting the Retinoic Acid Pathway to Eradicate Cancer Stem Cells.International journal of molecular sciences · 2023
    Review
  6. All About That Ras: Novel Fusion Drives Ras Pathway Activation in Lung Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  7. RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  8. Review
  9. Antagonizing RARγ Drives Necroptosis of Cancer Stem Cells.International journal of molecular sciences · 2022
    Review
  10. The RARγ Oncogene: An Achilles Heel for Some Cancers.International journal of molecular sciences · 2021
    Review
  11. Acute Myeloid Leukaemia: New Targets and Therapies.International journal of molecular sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Justin M WattsDivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. jxw401@miami.edu.
Aymee PerezDivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. aperez10@med.miami.edu.
Lutecia PereiraDivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. lpereira@med.miami.edu.
Yao-Shan FanDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. yfan@med.miami.edu.
Geoffrey BrownInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK. g.brown@bham.ac.uk.
Francisco VegaDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. fvega@med.miami.edu.
Kevin PetrieFaculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK. kevin.petrie@stir.ac.uk.
Ronan T SwordsDivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. rswords@med.miami.edu.
Arthur ZelentDivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. a.zelent@med.miami.edu.
University of Miami · USUniversity of Birmingham · GBUniversity of Stirling · GB

Funding

Miami Clinical and Translational Science InstituteKL2TR000461 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SACCO, RALPH L. · 2012 to 2016
$2.1M
NCATS NIH HHS KL2 TR000461
6 · The paper itself

Abstract

Here we report the case of a 30-year-old woman with relapsed acute myeloid leukemia (AML) who was treated with all-

Indexed as

Cells, CulturedFemaleHumansKaryotypingLeukemia, Myeloid, AcuteMembrane Proteinsras-GRF1RetinoidsTranscription FactorsTranslocation, GeneticTretinoinMembrane Proteinsras-GRF1RetinoidsTMEM154 protein, humanTranscription FactorsTretinoin15)(q31acute myeloid leukemiaATRANCT02273102q22)retinoidt(4TMEM154-RASGRF1

Identifiers

PMID28696354
PMCPMC5535982
OpenAlexW2736088244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.