ArticleProceedings of the National Academy of Sciences of the United States of America2017
Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Modulation and Gating of Transthalamic and Subcortical Pathways through Somatosensory Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Synaptic integration of somatosensory and motor cortical inputs onto spiny projection neurons of mice caudoputamen.The European journal of neuroscience · 2024Article
- Transthalamic Pathways for Cortical Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice.Cell reports. Medicine · 2024Article
- Advanced Methodology for Neurophysiological Analysis and Biomarker Development: Time-Frequency and Source-Localization Approaches.Advances in neurobiology · 2024Review
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- Layer 5 of cortex innervates the thalamic reticular nucleus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Conserved patterns of functional organization between cortex and thalamus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Integration of signals from different cortical areas in higher order thalamic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1.eLife · 2021Article
- Distinct functional developments of surviving and eliminated presynaptic terminals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Morphologic Characterization of Trigeminothalamic Terminal Arbors Arising From the Principal Nucleus in the Macaque.Frontiers in neuroanatomy · 2020Article
- A repeated molecular architecture across thalamic pathways.Nature neuroscience · 2019Article
- A Sensorimotor Pathway via Higher-Order Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Somatosensory information is thought to arrive in thalamus through two glutamatergic routes called the lemniscal and paralemniscal pathways via the ventral posterior medial (VPm) and posterior medial (POm) nuclei. Here we challenge the view that these pathways functionally represent parallel information routes. Using electrical stimulation and an optogenetic approach in brain slices from the mouse, we investigated the synaptic properties of the lemniscal and paralemniscal input to VPm and POm. Stimulation of the lemniscal pathway produced class 1, or "driver," responses in VPm relay cells, which is consistent with this being an information-bearing channel. However, stimulation of the paralemniscal pathway produced two distinct types of responses in POm relay cells: class 1 (driver) responses in 29% of the cells, and class 2, or "modulator," responses in the rest. Our data suggest that, unlike the lemniscal pathway, the paralemniscal one is not homogenous and that it is primarily modulatory. This finding requires major rethinking regarding the routes of somatosensory information to cortex and suggests that the paralemniscal route is chiefly involved in modulatory functions rather than simply being an information route parallel to the lemniscal channel.
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