ArticleCirculation research2017
Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood.
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Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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37 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- The effects of housing temperature on mouse physiology and implications for disease modeling.Lab animal · 2026Review
- Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health.International journal of biological sciences · 2026Review
- Visualizing Immune Checkpoint Inhibitors Derived Inflammation in Atherosclerosis.Circulation research · 2024Article
- Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice.Nature communications · 2024Article
- Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences.International journal of molecular sciences · 2024Review
- Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Effect of repeatedly applied cold water immersion on subclinical atherosclerosis, inflammation, fat accumulation and lipid profile parameters of volunteers.Wiener klinische Wochenschrift · 2024Article
- Unravelling monocyte functions: from the guardians of health to the regulators of disease.Discovery immunology · 2024Review
- Article
- Multifaceted mitochondrial quality control in brown adipose tissue.Trends in cell biology · 2023Review
- The Influence of Ambient Temperature on Adipose Tissue Homeostasis, Metabolic Diseases and Cancers.Cells · 2023Review
- Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis.Genes and immunity · 2023Article
- Unravelling the role of macrophages in cardiovascular inflammation through imaging: a state-of-the-art review.European heart journal. Cardiovascular Imaging · 2022Review
- Unravelling the sex-specific diversity and functions of adrenal gland macrophages.Cell reports · 2022Article
- Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.Cell metabolism · 2022Article
- Immune cell involvement in brown adipose tissue functions.Discovery immunology · 2022Review
- Brown adipose tissue monocytes support tissue expansion.Nature communications · 2021Article
- Assessment of ultrasmall nanocluster for early and accurate detection of atherosclerosis using positron emission tomography/computed tomography.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
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Authors and funding
16 authors at 2 institutions in 2 countries.
Jesse W WilliamsFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Andrew ElvingtonFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Stoyan IvanovFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Skyler KesslerFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Hannah LuehmannFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Osamu BabaFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Brian T SaundersFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Ki-Wook KimFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Michael W JohnsonFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Clarissa S CraftFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Jae-Hoon ChoiFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Mary G Sorci-ThomasFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Bernd H ZinselmeyerFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Jonathan R BrestoffFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Yongjian LiuFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.).
Gwendalyn J RandolphFrom the Department of Pathology and Immunology (J.W.W., A.E., S.I., S.K., O.B., B.T.S., K.-W.K., M.W.J., J.-H.C., B.H.Z., J.R.B., G.J.R.), Department of Radiology (H.L., Y.L.), and Department of Medicine, Division of Bone and Mineral Diseases (C.S.C.), Washington University School of Medicine, St. Louis, MO; Division of Health and Sport Sciences, Missouri Baptist University, St. Louis (A.E.); Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea (J.-H.C.); and Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee (M.G.S.-T.). gjrandolph@wustl.edu.
Missouri Baptist University · USHanyang University · KR
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1MDIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7MPRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6MDIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3MINTEGRATING CELL & LIPOPROTEIN TRAFFICKING WITH VASCULAR BIOLOGY IN HUMAN IBDDP1DK109668 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2015 to 2019
$3.8MT Regulatory Lymphocytes, HDL Function, and AtherosclerosisR01HL112276 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HEDRICK, CATHERINE C, SORCI-THOMAS, MARY G · 2013 to 2016
$2.8MSR-BI and PCPE2: Novel partners in bi-directional cholesterol transportR01HL138907 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SAHOO, DAISY, SORCI-THOMAS, MARY G · 2018 to 2021
$2.8MBiogenesis of HDL Through Cholesterol Efflux and ApoA-I Structural ReorganizationR01HL127649 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SORCI-THOMAS, MARY G · 2015 to 2018
$2.2MPET IMAGING CCR2 IN LUNG INFLAMMATIONR01HL131908 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN, LIU, YONGJIAN · 2016 to 2018
$2.0MVEGF-C/VEGFR3 AND LYMPHATIC TRANSPORT OF CHOLESTEROL FROM ATHEROSCLEROTIC PLAQUER01HL118206 · NHLBI · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2014 to 2017
$1.5MCHEMOKINE RECEPTORS BASED NANOAGENTS IMAGING ATHEROSCLEROSISR01HL125655 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2015 to 2018
$1.5MNHLBI NIH HHS R01 HL112276NHLBI NIH HHS R01 HL118206NHLBI NIH HHS R01 HL125655NHLBI NIH HHS R01 HL127649NHLBI NIH HHS R01 HL131908NHLBI NIH HHS R01 HL138907NHLBI NIH HHS T32 HL007081NIAID NIH HHS R37 AI049653NIA NIH HHS R21 AG046743NIDA NIH HHS R21 DA046734NIDDK NIH HHS DP1 DK109668NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS T32 DK007120
Abstract
rationaleAmbient temperature is a risk factor for cardiovascular disease. Cold weather increases cardiovascular events, but paradoxically, cold exposure is metabolically protective because of UCP1 (uncoupling protein 1)-dependent thermogenesis.
objectiveWe sought to determine the differential effects of ambient environmental temperature challenge and UCP1 activation in relation to cardiovascular disease progression. METHODS AND
resultsUsing mouse models of atherosclerosis housed at 3 different ambient temperatures, we observed that cold temperature enhanced, whereas thermoneutral housing temperature inhibited atherosclerotic plaque growth, as did deficiency in UCP1. However, whereas UCP1 deficiency promoted poor glucose tolerance, thermoneutral housing enhanced glucose tolerance, and this effect held even in the context of UCP1 deficiency. In conditions of thermoneutrality, but not UCP1 deficiency, circulating monocyte counts were reduced, likely accounting for fewer monocytes entering plaques. Reductions in circulating blood monocytes were also found in a large human cohort in correlation with environmental temperature. By contrast, reduced plaque growth in mice lacking UCP1 was linked to lower cholesterol. Through application of a positron emission tomographic tracer to track CCR2
conclusionsWarm ambient temperature is, like UCP1 deficiency, atheroprotective, but the mechanisms of action differ. Thermoneutrality associates with reduced monocyte egress from the bone marrow in a UCP1-dependent manner in mice and likewise may also suppress blood monocyte counts in man.
Indexed as
ThermogenesisAnimalsAtherosclerosisCell MovementCholesterolCold TemperatureHumansMiceMice, Inbred C57BLMonocytesPlaque, AtheroscleroticReceptors, CCR2Uncoupling Protein 1Ccr2 protein, mouseCholesterolReceptors, CCR2Ucp1 protein, mouseUncoupling Protein 1atherosclerosisbone marrowhousingmacrophagesthermogenesis
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